Cargando…
Evaluating the potential of matrix metalloproteinase as a diagnostic biomarker in rheumatoid arthritis and periodontitis: A systematic review and meta-analysis
BACKGROUND: Matrix metalloproteinases (MMPs) play a crucial role in the pathogenesis of several chronic diseases including rheumatoid arthritis (RA) and periodontitis (PD). RA patients with periodontitis (RA-PD) are associated with elevated inflammatory burden due to increased production of proinfla...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578754/ https://www.ncbi.nlm.nih.gov/pubmed/37832126 http://dx.doi.org/10.1097/MD.0000000000035340 |
_version_ | 1785121577586655232 |
---|---|
author | Batool, Aimen Vaithilingam, Rathna Devi Mohamad Hassan, Norul Husna Safii, Syarida Hasnur Saub, Roslan |
author_facet | Batool, Aimen Vaithilingam, Rathna Devi Mohamad Hassan, Norul Husna Safii, Syarida Hasnur Saub, Roslan |
author_sort | Batool, Aimen |
collection | PubMed |
description | BACKGROUND: Matrix metalloproteinases (MMPs) play a crucial role in the pathogenesis of several chronic diseases including rheumatoid arthritis (RA) and periodontitis (PD). RA patients with periodontitis (RA-PD) are associated with elevated inflammatory burden due to increased production of proinflammatory cytokines. Controlling upregulated MMPs activity in these patients may have potential therapeutic effects. Therefore, aim of this study is to address the focused question: “Do RA subjects with concurrent PD have different levels of MMPs in comparison to RA alone, PD alone and HC subjects?” METHODS: The systematic review was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A search from 4 electronic databases (EMBASE, Medline, Web of Science, and Cochrane library) and manual search was performed from inception to July 2023. Quality assessment of each article was done using Newcastle-Ottawa Scale. Meta-analyses derived results were summarized as standardized mean difference (SMD) with 95% confidence intervals. RESULTS: A total of 879 articles were extracted. Following screening and full text assessment, 9 studies were included. MMP-1, MMP-3, MMP-8, MMP-9, and MMP-13 were consistently elevated in RA-PD subjects. MMP-8 levels were found to be higher in RA-PD subjects compared with RA alone, PD alone, and HC in 3 studies reporting GCF levels (SMD = 1.2; Z = 2.07; P = .04) and 2 studies reporting serum levels (SMD = 0.87; Z = 4.53; P < .00001). CONCLUSION: RA-PD group showed significantly higher MMP levels in their serum and GCF compared with HC, RA, and PD alone individuals. MMP-8 may serve as a reliable biomarker in the diagnosis and management of RA-PD subjects. |
format | Online Article Text |
id | pubmed-10578754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-105787542023-10-17 Evaluating the potential of matrix metalloproteinase as a diagnostic biomarker in rheumatoid arthritis and periodontitis: A systematic review and meta-analysis Batool, Aimen Vaithilingam, Rathna Devi Mohamad Hassan, Norul Husna Safii, Syarida Hasnur Saub, Roslan Medicine (Baltimore) 5900 BACKGROUND: Matrix metalloproteinases (MMPs) play a crucial role in the pathogenesis of several chronic diseases including rheumatoid arthritis (RA) and periodontitis (PD). RA patients with periodontitis (RA-PD) are associated with elevated inflammatory burden due to increased production of proinflammatory cytokines. Controlling upregulated MMPs activity in these patients may have potential therapeutic effects. Therefore, aim of this study is to address the focused question: “Do RA subjects with concurrent PD have different levels of MMPs in comparison to RA alone, PD alone and HC subjects?” METHODS: The systematic review was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A search from 4 electronic databases (EMBASE, Medline, Web of Science, and Cochrane library) and manual search was performed from inception to July 2023. Quality assessment of each article was done using Newcastle-Ottawa Scale. Meta-analyses derived results were summarized as standardized mean difference (SMD) with 95% confidence intervals. RESULTS: A total of 879 articles were extracted. Following screening and full text assessment, 9 studies were included. MMP-1, MMP-3, MMP-8, MMP-9, and MMP-13 were consistently elevated in RA-PD subjects. MMP-8 levels were found to be higher in RA-PD subjects compared with RA alone, PD alone, and HC in 3 studies reporting GCF levels (SMD = 1.2; Z = 2.07; P = .04) and 2 studies reporting serum levels (SMD = 0.87; Z = 4.53; P < .00001). CONCLUSION: RA-PD group showed significantly higher MMP levels in their serum and GCF compared with HC, RA, and PD alone individuals. MMP-8 may serve as a reliable biomarker in the diagnosis and management of RA-PD subjects. Lippincott Williams & Wilkins 2023-10-13 /pmc/articles/PMC10578754/ /pubmed/37832126 http://dx.doi.org/10.1097/MD.0000000000035340 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | 5900 Batool, Aimen Vaithilingam, Rathna Devi Mohamad Hassan, Norul Husna Safii, Syarida Hasnur Saub, Roslan Evaluating the potential of matrix metalloproteinase as a diagnostic biomarker in rheumatoid arthritis and periodontitis: A systematic review and meta-analysis |
title | Evaluating the potential of matrix metalloproteinase as a diagnostic biomarker in rheumatoid arthritis and periodontitis: A systematic review and meta-analysis |
title_full | Evaluating the potential of matrix metalloproteinase as a diagnostic biomarker in rheumatoid arthritis and periodontitis: A systematic review and meta-analysis |
title_fullStr | Evaluating the potential of matrix metalloproteinase as a diagnostic biomarker in rheumatoid arthritis and periodontitis: A systematic review and meta-analysis |
title_full_unstemmed | Evaluating the potential of matrix metalloproteinase as a diagnostic biomarker in rheumatoid arthritis and periodontitis: A systematic review and meta-analysis |
title_short | Evaluating the potential of matrix metalloproteinase as a diagnostic biomarker in rheumatoid arthritis and periodontitis: A systematic review and meta-analysis |
title_sort | evaluating the potential of matrix metalloproteinase as a diagnostic biomarker in rheumatoid arthritis and periodontitis: a systematic review and meta-analysis |
topic | 5900 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578754/ https://www.ncbi.nlm.nih.gov/pubmed/37832126 http://dx.doi.org/10.1097/MD.0000000000035340 |
work_keys_str_mv | AT batoolaimen evaluatingthepotentialofmatrixmetalloproteinaseasadiagnosticbiomarkerinrheumatoidarthritisandperiodontitisasystematicreviewandmetaanalysis AT vaithilingamrathnadevi evaluatingthepotentialofmatrixmetalloproteinaseasadiagnosticbiomarkerinrheumatoidarthritisandperiodontitisasystematicreviewandmetaanalysis AT mohamadhassannorulhusna evaluatingthepotentialofmatrixmetalloproteinaseasadiagnosticbiomarkerinrheumatoidarthritisandperiodontitisasystematicreviewandmetaanalysis AT safiisyaridahasnur evaluatingthepotentialofmatrixmetalloproteinaseasadiagnosticbiomarkerinrheumatoidarthritisandperiodontitisasystematicreviewandmetaanalysis AT saubroslan evaluatingthepotentialofmatrixmetalloproteinaseasadiagnosticbiomarkerinrheumatoidarthritisandperiodontitisasystematicreviewandmetaanalysis |