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A retrospective study of Kaposi’s sarcoma in Hotan region of Xinjiang, China
Kaposi sarcoma (KS) is the most common cancer in patients with human immunodeficiency virus/acquired immunodeficiency syndrome (AIDS). In 1994, Chang and Moore discovered Kaposi sarcoma associated herpesvirus for the first time in KS lesions in AIDS patients. KS is a low-grade mesenchymal neoplasm o...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578766/ https://www.ncbi.nlm.nih.gov/pubmed/37832074 http://dx.doi.org/10.1097/MD.0000000000035552 |
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author | Yang, Hong Liang He, Feng Jielili, Aibibai Zhang, Zhi Rong Cui, Zhi Yong Wang, Jin Hua Guo, Hai Tao |
author_facet | Yang, Hong Liang He, Feng Jielili, Aibibai Zhang, Zhi Rong Cui, Zhi Yong Wang, Jin Hua Guo, Hai Tao |
author_sort | Yang, Hong Liang |
collection | PubMed |
description | Kaposi sarcoma (KS) is the most common cancer in patients with human immunodeficiency virus/acquired immunodeficiency syndrome (AIDS). In 1994, Chang and Moore discovered Kaposi sarcoma associated herpesvirus for the first time in KS lesions in AIDS patients. KS is a low-grade mesenchymal neoplasm of blood and lymphatic vessels that primarily affects the skin, although the disease may become disseminated to the lymphatic system, lungs, airways, or abdominal viscera. In this research, clinical characteristics and treatment of patients of Kaposi sarcoma were retrospectively analyzed in Hotan District, Xinjiang China. We look into the clinical traits, prognosis, and therapy of Kaposi sarcoma. From May 2017 to August 2022, 32 patients were treated in the People’s Hospital of Hotan District, Xinjiang Uygur Autonomous Region, China. Twenty-two of these were classic Kaposi sarcomas (cKS), and 10 of these were Kaposi sarcomas linked to AIDS (AIDS-KS). The majority of KS patients were Uyghur. In terms of age at onset, AIDS-KS patients were younger than cKS patients. cKS and AIDS-KS are most frequently manifested in the feet and lower limbs. Ten patients with AIDS-KS have treated with combination antiretroviral therapy (combination antiretroviral therapy) combination chemotherapy, 5 of 10 patients had a complete response, 2 patients achieved partial response, the overall effective rate was 70%, and CD4 + T cells were greater than before. For cKS and AIDS-KS, the median overall survival was 56 and 50.8 months, respectively (P > .05). As a result, antiviral combination chemotherapy can also improve the prognosis of AIDS-KS patients. |
format | Online Article Text |
id | pubmed-10578766 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-105787662023-10-17 A retrospective study of Kaposi’s sarcoma in Hotan region of Xinjiang, China Yang, Hong Liang He, Feng Jielili, Aibibai Zhang, Zhi Rong Cui, Zhi Yong Wang, Jin Hua Guo, Hai Tao Medicine (Baltimore) Research Article: Observational Study Kaposi sarcoma (KS) is the most common cancer in patients with human immunodeficiency virus/acquired immunodeficiency syndrome (AIDS). In 1994, Chang and Moore discovered Kaposi sarcoma associated herpesvirus for the first time in KS lesions in AIDS patients. KS is a low-grade mesenchymal neoplasm of blood and lymphatic vessels that primarily affects the skin, although the disease may become disseminated to the lymphatic system, lungs, airways, or abdominal viscera. In this research, clinical characteristics and treatment of patients of Kaposi sarcoma were retrospectively analyzed in Hotan District, Xinjiang China. We look into the clinical traits, prognosis, and therapy of Kaposi sarcoma. From May 2017 to August 2022, 32 patients were treated in the People’s Hospital of Hotan District, Xinjiang Uygur Autonomous Region, China. Twenty-two of these were classic Kaposi sarcomas (cKS), and 10 of these were Kaposi sarcomas linked to AIDS (AIDS-KS). The majority of KS patients were Uyghur. In terms of age at onset, AIDS-KS patients were younger than cKS patients. cKS and AIDS-KS are most frequently manifested in the feet and lower limbs. Ten patients with AIDS-KS have treated with combination antiretroviral therapy (combination antiretroviral therapy) combination chemotherapy, 5 of 10 patients had a complete response, 2 patients achieved partial response, the overall effective rate was 70%, and CD4 + T cells were greater than before. For cKS and AIDS-KS, the median overall survival was 56 and 50.8 months, respectively (P > .05). As a result, antiviral combination chemotherapy can also improve the prognosis of AIDS-KS patients. Lippincott Williams & Wilkins 2023-10-13 /pmc/articles/PMC10578766/ /pubmed/37832074 http://dx.doi.org/10.1097/MD.0000000000035552 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | Research Article: Observational Study Yang, Hong Liang He, Feng Jielili, Aibibai Zhang, Zhi Rong Cui, Zhi Yong Wang, Jin Hua Guo, Hai Tao A retrospective study of Kaposi’s sarcoma in Hotan region of Xinjiang, China |
title | A retrospective study of Kaposi’s sarcoma in Hotan region of Xinjiang, China |
title_full | A retrospective study of Kaposi’s sarcoma in Hotan region of Xinjiang, China |
title_fullStr | A retrospective study of Kaposi’s sarcoma in Hotan region of Xinjiang, China |
title_full_unstemmed | A retrospective study of Kaposi’s sarcoma in Hotan region of Xinjiang, China |
title_short | A retrospective study of Kaposi’s sarcoma in Hotan region of Xinjiang, China |
title_sort | retrospective study of kaposi’s sarcoma in hotan region of xinjiang, china |
topic | Research Article: Observational Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578766/ https://www.ncbi.nlm.nih.gov/pubmed/37832074 http://dx.doi.org/10.1097/MD.0000000000035552 |
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