Cargando…

A retrospective study of Kaposi’s sarcoma in Hotan region of Xinjiang, China

Kaposi sarcoma (KS) is the most common cancer in patients with human immunodeficiency virus/acquired immunodeficiency syndrome (AIDS). In 1994, Chang and Moore discovered Kaposi sarcoma associated herpesvirus for the first time in KS lesions in AIDS patients. KS is a low-grade mesenchymal neoplasm o...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Hong Liang, He, Feng, Jielili, Aibibai, Zhang, Zhi Rong, Cui, Zhi Yong, Wang, Jin Hua, Guo, Hai Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578766/
https://www.ncbi.nlm.nih.gov/pubmed/37832074
http://dx.doi.org/10.1097/MD.0000000000035552
_version_ 1785121580464996352
author Yang, Hong Liang
He, Feng
Jielili, Aibibai
Zhang, Zhi Rong
Cui, Zhi Yong
Wang, Jin Hua
Guo, Hai Tao
author_facet Yang, Hong Liang
He, Feng
Jielili, Aibibai
Zhang, Zhi Rong
Cui, Zhi Yong
Wang, Jin Hua
Guo, Hai Tao
author_sort Yang, Hong Liang
collection PubMed
description Kaposi sarcoma (KS) is the most common cancer in patients with human immunodeficiency virus/acquired immunodeficiency syndrome (AIDS). In 1994, Chang and Moore discovered Kaposi sarcoma associated herpesvirus for the first time in KS lesions in AIDS patients. KS is a low-grade mesenchymal neoplasm of blood and lymphatic vessels that primarily affects the skin, although the disease may become disseminated to the lymphatic system, lungs, airways, or abdominal viscera. In this research, clinical characteristics and treatment of patients of Kaposi sarcoma were retrospectively analyzed in Hotan District, Xinjiang China. We look into the clinical traits, prognosis, and therapy of Kaposi sarcoma. From May 2017 to August 2022, 32 patients were treated in the People’s Hospital of Hotan District, Xinjiang Uygur Autonomous Region, China. Twenty-two of these were classic Kaposi sarcomas (cKS), and 10 of these were Kaposi sarcomas linked to AIDS (AIDS-KS). The majority of KS patients were Uyghur. In terms of age at onset, AIDS-KS patients were younger than cKS patients. cKS and AIDS-KS are most frequently manifested in the feet and lower limbs. Ten patients with AIDS-KS have treated with combination antiretroviral therapy (combination antiretroviral therapy) combination chemotherapy, 5 of 10 patients had a complete response, 2 patients achieved partial response, the overall effective rate was 70%, and CD4 + T cells were greater than before. For cKS and AIDS-KS, the median overall survival was 56 and 50.8 months, respectively (P > .05). As a result, antiviral combination chemotherapy can also improve the prognosis of AIDS-KS patients.
format Online
Article
Text
id pubmed-10578766
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-105787662023-10-17 A retrospective study of Kaposi’s sarcoma in Hotan region of Xinjiang, China Yang, Hong Liang He, Feng Jielili, Aibibai Zhang, Zhi Rong Cui, Zhi Yong Wang, Jin Hua Guo, Hai Tao Medicine (Baltimore) Research Article: Observational Study Kaposi sarcoma (KS) is the most common cancer in patients with human immunodeficiency virus/acquired immunodeficiency syndrome (AIDS). In 1994, Chang and Moore discovered Kaposi sarcoma associated herpesvirus for the first time in KS lesions in AIDS patients. KS is a low-grade mesenchymal neoplasm of blood and lymphatic vessels that primarily affects the skin, although the disease may become disseminated to the lymphatic system, lungs, airways, or abdominal viscera. In this research, clinical characteristics and treatment of patients of Kaposi sarcoma were retrospectively analyzed in Hotan District, Xinjiang China. We look into the clinical traits, prognosis, and therapy of Kaposi sarcoma. From May 2017 to August 2022, 32 patients were treated in the People’s Hospital of Hotan District, Xinjiang Uygur Autonomous Region, China. Twenty-two of these were classic Kaposi sarcomas (cKS), and 10 of these were Kaposi sarcomas linked to AIDS (AIDS-KS). The majority of KS patients were Uyghur. In terms of age at onset, AIDS-KS patients were younger than cKS patients. cKS and AIDS-KS are most frequently manifested in the feet and lower limbs. Ten patients with AIDS-KS have treated with combination antiretroviral therapy (combination antiretroviral therapy) combination chemotherapy, 5 of 10 patients had a complete response, 2 patients achieved partial response, the overall effective rate was 70%, and CD4 + T cells were greater than before. For cKS and AIDS-KS, the median overall survival was 56 and 50.8 months, respectively (P > .05). As a result, antiviral combination chemotherapy can also improve the prognosis of AIDS-KS patients. Lippincott Williams & Wilkins 2023-10-13 /pmc/articles/PMC10578766/ /pubmed/37832074 http://dx.doi.org/10.1097/MD.0000000000035552 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle Research Article: Observational Study
Yang, Hong Liang
He, Feng
Jielili, Aibibai
Zhang, Zhi Rong
Cui, Zhi Yong
Wang, Jin Hua
Guo, Hai Tao
A retrospective study of Kaposi’s sarcoma in Hotan region of Xinjiang, China
title A retrospective study of Kaposi’s sarcoma in Hotan region of Xinjiang, China
title_full A retrospective study of Kaposi’s sarcoma in Hotan region of Xinjiang, China
title_fullStr A retrospective study of Kaposi’s sarcoma in Hotan region of Xinjiang, China
title_full_unstemmed A retrospective study of Kaposi’s sarcoma in Hotan region of Xinjiang, China
title_short A retrospective study of Kaposi’s sarcoma in Hotan region of Xinjiang, China
title_sort retrospective study of kaposi’s sarcoma in hotan region of xinjiang, china
topic Research Article: Observational Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578766/
https://www.ncbi.nlm.nih.gov/pubmed/37832074
http://dx.doi.org/10.1097/MD.0000000000035552
work_keys_str_mv AT yanghongliang aretrospectivestudyofkaposissarcomainhotanregionofxinjiangchina
AT hefeng aretrospectivestudyofkaposissarcomainhotanregionofxinjiangchina
AT jieliliaibibai aretrospectivestudyofkaposissarcomainhotanregionofxinjiangchina
AT zhangzhirong aretrospectivestudyofkaposissarcomainhotanregionofxinjiangchina
AT cuizhiyong aretrospectivestudyofkaposissarcomainhotanregionofxinjiangchina
AT wangjinhua aretrospectivestudyofkaposissarcomainhotanregionofxinjiangchina
AT guohaitao aretrospectivestudyofkaposissarcomainhotanregionofxinjiangchina
AT yanghongliang retrospectivestudyofkaposissarcomainhotanregionofxinjiangchina
AT hefeng retrospectivestudyofkaposissarcomainhotanregionofxinjiangchina
AT jieliliaibibai retrospectivestudyofkaposissarcomainhotanregionofxinjiangchina
AT zhangzhirong retrospectivestudyofkaposissarcomainhotanregionofxinjiangchina
AT cuizhiyong retrospectivestudyofkaposissarcomainhotanregionofxinjiangchina
AT wangjinhua retrospectivestudyofkaposissarcomainhotanregionofxinjiangchina
AT guohaitao retrospectivestudyofkaposissarcomainhotanregionofxinjiangchina