Plasma β‐synuclein, GFAP, and neurofilaments in patients with malignant gliomas undergoing surgical and adjuvant therapy

We analyzed the longitudinal concentrations and prognostic roles of plasma β‐synuclein (β‐syn), glial fibrillary acidic protein (GFAP), and neurofilament proteins (NfL and NfH) in 33 patients with malignant gliomas, who underwent surgical and adjuvant therapy. GFAP and NfL levels were increased in p...

Descripción completa

Detalles Bibliográficos
Autores principales: Abu‐Rumeileh, Samir, Barba, Lorenzo, Bache, Matthias, Halbgebauer, Steffen, Oeckl, Patrick, Steinacker, Petra, Güttler, Antje, Keßler, Jacqueline, Illert, Jörg, Strauss, Christian, Vordermark, Dirk, Otto, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578894/
https://www.ncbi.nlm.nih.gov/pubmed/37608748
http://dx.doi.org/10.1002/acn3.51878
Descripción
Sumario:We analyzed the longitudinal concentrations and prognostic roles of plasma β‐synuclein (β‐syn), glial fibrillary acidic protein (GFAP), and neurofilament proteins (NfL and NfH) in 33 patients with malignant gliomas, who underwent surgical and adjuvant therapy. GFAP and NfL levels were increased in patients with glioblastoma compared to cases with other tumors. β‐syn, NfL and NfH increased after surgery, whereas GFAP decreased at long‐term follow‐up. β‐syn and neurofilament concentrations were influenced by surgery and/or radiotherapy regimens. GFAP and neurofilament levels were significantly associated with survival. Plasma neuronal and astrocytic biomarkers are differentially altered in malignant glioma types and displayed distinct trajectories after surgical and adjuvant therapy.

Ejemplares similares