Plasma β‐synuclein, GFAP, and neurofilaments in patients with malignant gliomas undergoing surgical and adjuvant therapy

We analyzed the longitudinal concentrations and prognostic roles of plasma β‐synuclein (β‐syn), glial fibrillary acidic protein (GFAP), and neurofilament proteins (NfL and NfH) in 33 patients with malignant gliomas, who underwent surgical and adjuvant therapy. GFAP and NfL levels were increased in p...

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Autores principales: Abu‐Rumeileh, Samir, Barba, Lorenzo, Bache, Matthias, Halbgebauer, Steffen, Oeckl, Patrick, Steinacker, Petra, Güttler, Antje, Keßler, Jacqueline, Illert, Jörg, Strauss, Christian, Vordermark, Dirk, Otto, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578894/
https://www.ncbi.nlm.nih.gov/pubmed/37608748
http://dx.doi.org/10.1002/acn3.51878
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author Abu‐Rumeileh, Samir
Barba, Lorenzo
Bache, Matthias
Halbgebauer, Steffen
Oeckl, Patrick
Steinacker, Petra
Güttler, Antje
Keßler, Jacqueline
Illert, Jörg
Strauss, Christian
Vordermark, Dirk
Otto, Markus
author_facet Abu‐Rumeileh, Samir
Barba, Lorenzo
Bache, Matthias
Halbgebauer, Steffen
Oeckl, Patrick
Steinacker, Petra
Güttler, Antje
Keßler, Jacqueline
Illert, Jörg
Strauss, Christian
Vordermark, Dirk
Otto, Markus
author_sort Abu‐Rumeileh, Samir
collection PubMed
description We analyzed the longitudinal concentrations and prognostic roles of plasma β‐synuclein (β‐syn), glial fibrillary acidic protein (GFAP), and neurofilament proteins (NfL and NfH) in 33 patients with malignant gliomas, who underwent surgical and adjuvant therapy. GFAP and NfL levels were increased in patients with glioblastoma compared to cases with other tumors. β‐syn, NfL and NfH increased after surgery, whereas GFAP decreased at long‐term follow‐up. β‐syn and neurofilament concentrations were influenced by surgery and/or radiotherapy regimens. GFAP and neurofilament levels were significantly associated with survival. Plasma neuronal and astrocytic biomarkers are differentially altered in malignant glioma types and displayed distinct trajectories after surgical and adjuvant therapy.
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spelling pubmed-105788942023-10-17 Plasma β‐synuclein, GFAP, and neurofilaments in patients with malignant gliomas undergoing surgical and adjuvant therapy Abu‐Rumeileh, Samir Barba, Lorenzo Bache, Matthias Halbgebauer, Steffen Oeckl, Patrick Steinacker, Petra Güttler, Antje Keßler, Jacqueline Illert, Jörg Strauss, Christian Vordermark, Dirk Otto, Markus Ann Clin Transl Neurol Brief Communications We analyzed the longitudinal concentrations and prognostic roles of plasma β‐synuclein (β‐syn), glial fibrillary acidic protein (GFAP), and neurofilament proteins (NfL and NfH) in 33 patients with malignant gliomas, who underwent surgical and adjuvant therapy. GFAP and NfL levels were increased in patients with glioblastoma compared to cases with other tumors. β‐syn, NfL and NfH increased after surgery, whereas GFAP decreased at long‐term follow‐up. β‐syn and neurofilament concentrations were influenced by surgery and/or radiotherapy regimens. GFAP and neurofilament levels were significantly associated with survival. Plasma neuronal and astrocytic biomarkers are differentially altered in malignant glioma types and displayed distinct trajectories after surgical and adjuvant therapy. John Wiley and Sons Inc. 2023-08-23 /pmc/articles/PMC10578894/ /pubmed/37608748 http://dx.doi.org/10.1002/acn3.51878 Text en © 2023 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Abu‐Rumeileh, Samir
Barba, Lorenzo
Bache, Matthias
Halbgebauer, Steffen
Oeckl, Patrick
Steinacker, Petra
Güttler, Antje
Keßler, Jacqueline
Illert, Jörg
Strauss, Christian
Vordermark, Dirk
Otto, Markus
Plasma β‐synuclein, GFAP, and neurofilaments in patients with malignant gliomas undergoing surgical and adjuvant therapy
title Plasma β‐synuclein, GFAP, and neurofilaments in patients with malignant gliomas undergoing surgical and adjuvant therapy
title_full Plasma β‐synuclein, GFAP, and neurofilaments in patients with malignant gliomas undergoing surgical and adjuvant therapy
title_fullStr Plasma β‐synuclein, GFAP, and neurofilaments in patients with malignant gliomas undergoing surgical and adjuvant therapy
title_full_unstemmed Plasma β‐synuclein, GFAP, and neurofilaments in patients with malignant gliomas undergoing surgical and adjuvant therapy
title_short Plasma β‐synuclein, GFAP, and neurofilaments in patients with malignant gliomas undergoing surgical and adjuvant therapy
title_sort plasma β‐synuclein, gfap, and neurofilaments in patients with malignant gliomas undergoing surgical and adjuvant therapy
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578894/
https://www.ncbi.nlm.nih.gov/pubmed/37608748
http://dx.doi.org/10.1002/acn3.51878
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