Association between brain health outcomes and metabolic risk factors in persons with diabetes

We performed a cross‐sectional study to determine associations between cognition and MRI‐derived brain outcomes, with obesity, diabetes duration, and metabolic risk factors in 51 Pima American Indians with longstanding type 2 diabetes (T2d) (mean [SD] age: 48.4 [11.3] years, T2d duration: 20.1 [9.1]...

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Autores principales: Reynolds, Evan L., Votruba, Kristen, Jack, Clifford R., Beare, Richard, Reid, Robert I., Preboske, Gregory M., Waseta, Camille, Pop‐Busui, Rodica, Nelson, Robert G., Callaghan, Brian C., Feldman, Eva L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578900/
https://www.ncbi.nlm.nih.gov/pubmed/37518982
http://dx.doi.org/10.1002/acn3.51859
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author Reynolds, Evan L.
Votruba, Kristen
Jack, Clifford R.
Beare, Richard
Reid, Robert I.
Preboske, Gregory M.
Waseta, Camille
Pop‐Busui, Rodica
Nelson, Robert G.
Callaghan, Brian C.
Feldman, Eva L.
author_facet Reynolds, Evan L.
Votruba, Kristen
Jack, Clifford R.
Beare, Richard
Reid, Robert I.
Preboske, Gregory M.
Waseta, Camille
Pop‐Busui, Rodica
Nelson, Robert G.
Callaghan, Brian C.
Feldman, Eva L.
author_sort Reynolds, Evan L.
collection PubMed
description We performed a cross‐sectional study to determine associations between cognition and MRI‐derived brain outcomes, with obesity, diabetes duration, and metabolic risk factors in 51 Pima American Indians with longstanding type 2 diabetes (T2d) (mean [SD] age: 48.4 [11.3] years, T2d duration: 20.1 [9.1] years). Participants had similar cognition (NIH Toolbox Cognition Battery composite: 45.3 [9.8], p = 0.64, n = 51) compared to normative data. T2d duration, but not other metabolic risk factors, associated with decreased cortical thickness (Point Estimate (PE): −0.0061, 95%CI: −0.0113, −0.0009, n = 45), gray matter volume (PE: −830.39, 95%CI: −1503.14, −157.64, n = 45), and increased white matter hyperintensity volume (PE: 0.0389, 95%CI: 0.0049, 0.0729, n = 45).
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spelling pubmed-105789002023-10-17 Association between brain health outcomes and metabolic risk factors in persons with diabetes Reynolds, Evan L. Votruba, Kristen Jack, Clifford R. Beare, Richard Reid, Robert I. Preboske, Gregory M. Waseta, Camille Pop‐Busui, Rodica Nelson, Robert G. Callaghan, Brian C. Feldman, Eva L. Ann Clin Transl Neurol Brief Communications We performed a cross‐sectional study to determine associations between cognition and MRI‐derived brain outcomes, with obesity, diabetes duration, and metabolic risk factors in 51 Pima American Indians with longstanding type 2 diabetes (T2d) (mean [SD] age: 48.4 [11.3] years, T2d duration: 20.1 [9.1] years). Participants had similar cognition (NIH Toolbox Cognition Battery composite: 45.3 [9.8], p = 0.64, n = 51) compared to normative data. T2d duration, but not other metabolic risk factors, associated with decreased cortical thickness (Point Estimate (PE): −0.0061, 95%CI: −0.0113, −0.0009, n = 45), gray matter volume (PE: −830.39, 95%CI: −1503.14, −157.64, n = 45), and increased white matter hyperintensity volume (PE: 0.0389, 95%CI: 0.0049, 0.0729, n = 45). John Wiley and Sons Inc. 2023-07-30 /pmc/articles/PMC10578900/ /pubmed/37518982 http://dx.doi.org/10.1002/acn3.51859 Text en © 2023 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communications
Reynolds, Evan L.
Votruba, Kristen
Jack, Clifford R.
Beare, Richard
Reid, Robert I.
Preboske, Gregory M.
Waseta, Camille
Pop‐Busui, Rodica
Nelson, Robert G.
Callaghan, Brian C.
Feldman, Eva L.
Association between brain health outcomes and metabolic risk factors in persons with diabetes
title Association between brain health outcomes and metabolic risk factors in persons with diabetes
title_full Association between brain health outcomes and metabolic risk factors in persons with diabetes
title_fullStr Association between brain health outcomes and metabolic risk factors in persons with diabetes
title_full_unstemmed Association between brain health outcomes and metabolic risk factors in persons with diabetes
title_short Association between brain health outcomes and metabolic risk factors in persons with diabetes
title_sort association between brain health outcomes and metabolic risk factors in persons with diabetes
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578900/
https://www.ncbi.nlm.nih.gov/pubmed/37518982
http://dx.doi.org/10.1002/acn3.51859
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