Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic T(H)1 cell responses in Crohn’s disease

Aberrant CD4(+) T cell reactivity against intestinal microorganisms is considered to drive mucosal inflammation in inflammatory bowel diseases. The disease-relevant microbial species and the corresponding microorganism-specific, pathogenic T cell phenotypes remain largely unknown. In the present stu...

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Detalles Bibliográficos
Autores principales: Martini, Gabriela Rios, Tikhonova, Ekaterina, Rosati, Elisa, DeCelie, Meghan Bialt, Sievers, Laura Katharina, Tran, Florian, Lessing, Matthias, Bergfeld, Arne, Hinz, Sophia, Nikolaus, Susanna, Kümpers, Julia, Matysiak, Anna, Hofmann, Philipp, Saggau, Carina, Schneiders, Stephan, Kamps, Ann-Kristin, Jacobs, Gunnar, Lieb, Wolfgang, Maul, Jochen, Siegmund, Britta, Seegers, Barbara, Hinrichsen, Holger, Oberg, Hans-Heinrich, Wesch, Daniela, Bereswill, Stefan, Heimesaat, Markus M., Rupp, Jan, Kniemeyer, Olaf, Brakhage, Axel A., Brunke, Sascha, Hube, Bernhard, Aden, Konrad, Franke, Andre, Iliev, Iliyan D., Scheffold, Alexander, Schreiber, Stefan, Bacher, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579100/
https://www.ncbi.nlm.nih.gov/pubmed/37749331
http://dx.doi.org/10.1038/s41591-023-02556-5

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