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Indonesian marine and its medicinal contribution

The archipelagic country of Indonesia is populated by the densest marine biodiversity in the world which has created strong global interest and is valued by both Indigenous and European settlements for different purposes. Nearly 1000 chemicals have been extracted and identified. In this review, a sy...

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Autores principales: Nugraha, Ari Satia, Firli, Lilla Nur, Rani, Dinar Mutia, Hidayatiningsih, Ayunda, Lestari, Nadya Dini, Wongso, Hendris, Tarman, Kustiariyah, Rahaweman, Ayu Christien, Manurung, Jeprianto, Ariantari, Ni Putu, Papu, Adelfia, Putra, Masteria Yunovilsa, Pratama, Antonius Nugraha Widhi, Wessjohann, Ludger A., Keller, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579215/
https://www.ncbi.nlm.nih.gov/pubmed/37843645
http://dx.doi.org/10.1007/s13659-023-00403-1
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author Nugraha, Ari Satia
Firli, Lilla Nur
Rani, Dinar Mutia
Hidayatiningsih, Ayunda
Lestari, Nadya Dini
Wongso, Hendris
Tarman, Kustiariyah
Rahaweman, Ayu Christien
Manurung, Jeprianto
Ariantari, Ni Putu
Papu, Adelfia
Putra, Masteria Yunovilsa
Pratama, Antonius Nugraha Widhi
Wessjohann, Ludger A.
Keller, Paul A.
author_facet Nugraha, Ari Satia
Firli, Lilla Nur
Rani, Dinar Mutia
Hidayatiningsih, Ayunda
Lestari, Nadya Dini
Wongso, Hendris
Tarman, Kustiariyah
Rahaweman, Ayu Christien
Manurung, Jeprianto
Ariantari, Ni Putu
Papu, Adelfia
Putra, Masteria Yunovilsa
Pratama, Antonius Nugraha Widhi
Wessjohann, Ludger A.
Keller, Paul A.
author_sort Nugraha, Ari Satia
collection PubMed
description The archipelagic country of Indonesia is populated by the densest marine biodiversity in the world which has created strong global interest and is valued by both Indigenous and European settlements for different purposes. Nearly 1000 chemicals have been extracted and identified. In this review, a systematic data curation was employed to collate bioprospecting related manuscripts providing a comprehensive directory based on publications from 1988 to 2022. Findings with significant pharmacological activities are further discussed through a scoping data collection. This review discusses macroorganisms (Sponges, Ascidian, Gorgonians, Algae, Mangrove) and microorganism (Bacteria and Fungi) and highlights significant discoveries, including a potent microtubule stabilizer laulimalide from Hyattella sp., a prospective doxorubicin complement papuamine alkaloid from Neopetrosia cf exigua, potent antiplasmodial manzamine A from Acanthostrongylophora ingens, the highly potent anti trypanosomal manadoperoxide B from Plakortis cfr. Simplex, mRNA translation disrupter hippuristanol from Briareum sp, and the anti-HIV-1 (+)-8-hydroxymanzamine A isolated from Acanthostrongylophora sp. Further, some potent antibacterial extracts were also found from a limited biomass of bacteria cultures. Although there are currently no examples of commercial drugs from the Indonesian marine environment, this review shows the molecular diversity present and with the known understudied biodiversity, reveals great promise for future studies and outcomes. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-023-00403-1.
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spelling pubmed-105792152023-10-18 Indonesian marine and its medicinal contribution Nugraha, Ari Satia Firli, Lilla Nur Rani, Dinar Mutia Hidayatiningsih, Ayunda Lestari, Nadya Dini Wongso, Hendris Tarman, Kustiariyah Rahaweman, Ayu Christien Manurung, Jeprianto Ariantari, Ni Putu Papu, Adelfia Putra, Masteria Yunovilsa Pratama, Antonius Nugraha Widhi Wessjohann, Ludger A. Keller, Paul A. Nat Prod Bioprospect Review The archipelagic country of Indonesia is populated by the densest marine biodiversity in the world which has created strong global interest and is valued by both Indigenous and European settlements for different purposes. Nearly 1000 chemicals have been extracted and identified. In this review, a systematic data curation was employed to collate bioprospecting related manuscripts providing a comprehensive directory based on publications from 1988 to 2022. Findings with significant pharmacological activities are further discussed through a scoping data collection. This review discusses macroorganisms (Sponges, Ascidian, Gorgonians, Algae, Mangrove) and microorganism (Bacteria and Fungi) and highlights significant discoveries, including a potent microtubule stabilizer laulimalide from Hyattella sp., a prospective doxorubicin complement papuamine alkaloid from Neopetrosia cf exigua, potent antiplasmodial manzamine A from Acanthostrongylophora ingens, the highly potent anti trypanosomal manadoperoxide B from Plakortis cfr. Simplex, mRNA translation disrupter hippuristanol from Briareum sp, and the anti-HIV-1 (+)-8-hydroxymanzamine A isolated from Acanthostrongylophora sp. Further, some potent antibacterial extracts were also found from a limited biomass of bacteria cultures. Although there are currently no examples of commercial drugs from the Indonesian marine environment, this review shows the molecular diversity present and with the known understudied biodiversity, reveals great promise for future studies and outcomes. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-023-00403-1. Springer Nature Singapore 2023-10-16 /pmc/articles/PMC10579215/ /pubmed/37843645 http://dx.doi.org/10.1007/s13659-023-00403-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Nugraha, Ari Satia
Firli, Lilla Nur
Rani, Dinar Mutia
Hidayatiningsih, Ayunda
Lestari, Nadya Dini
Wongso, Hendris
Tarman, Kustiariyah
Rahaweman, Ayu Christien
Manurung, Jeprianto
Ariantari, Ni Putu
Papu, Adelfia
Putra, Masteria Yunovilsa
Pratama, Antonius Nugraha Widhi
Wessjohann, Ludger A.
Keller, Paul A.
Indonesian marine and its medicinal contribution
title Indonesian marine and its medicinal contribution
title_full Indonesian marine and its medicinal contribution
title_fullStr Indonesian marine and its medicinal contribution
title_full_unstemmed Indonesian marine and its medicinal contribution
title_short Indonesian marine and its medicinal contribution
title_sort indonesian marine and its medicinal contribution
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579215/
https://www.ncbi.nlm.nih.gov/pubmed/37843645
http://dx.doi.org/10.1007/s13659-023-00403-1
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