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Design, structure and plasma binding of ancestral β-CoV scaffold antigens

We report the application of ancestral sequence reconstruction on coronavirus spike protein, resulting in stable and highly soluble ancestral scaffold antigens (AnSAs). The AnSAs interact with plasma of patients recovered from COVID-19 but do not bind to the human angiotensin-converting enzyme 2 (AC...

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Detalles Bibliográficos
Autores principales:	Hueting, David, Schriever, Karen, Sun, Rui, Vlachiotis, Stelios, Zuo, Fanglei, Du, Likun, Persson, Helena, Hofström, Camilla, Ohlin, Mats, Walldén, Karin, Buggert, Marcus, Hammarström, Lennart, Marcotte, Harold, Pan-Hammarström, Qiang, Andréll, Juni, Syrén, Per-Olof
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579346/ https://www.ncbi.nlm.nih.gov/pubmed/37845250 http://dx.doi.org/10.1038/s41467-023-42200-x

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