Cargando…
RAG genomic variation causes autoimmune diseases through specific structure-based mechanisms of enzyme dysregulation
Interpreting genetic changes observed in individual patients is a critical challenge. The array of immune deficiency syndromes is typically caused by genetic variation unique to individuals. Therefore, new approaches are needed to interpret functional variation and accelerate genomics interpretation...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579426/ https://www.ncbi.nlm.nih.gov/pubmed/37854700 http://dx.doi.org/10.1016/j.isci.2023.108040 |