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Molecular regulation of neutrophil swarming in health and disease: Lessons from the phagocyte oxidase

Neutrophil swarming is a complex coordinated process in which neutrophils sensing pathogen or damage signals are rapidly recruited to sites of infections or injuries. This process involves cooperation between neutrophils where autocrine and paracrine positive-feedback loops, mediated by receptor/lig...

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Detalles Bibliográficos
Autores principales: Song, Zhimin, Bhattacharya, Sourav, Clemens, Regina A., Dinauer, Mary C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579437/
https://www.ncbi.nlm.nih.gov/pubmed/37854699
http://dx.doi.org/10.1016/j.isci.2023.108034
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author Song, Zhimin
Bhattacharya, Sourav
Clemens, Regina A.
Dinauer, Mary C.
author_facet Song, Zhimin
Bhattacharya, Sourav
Clemens, Regina A.
Dinauer, Mary C.
author_sort Song, Zhimin
collection PubMed
description Neutrophil swarming is a complex coordinated process in which neutrophils sensing pathogen or damage signals are rapidly recruited to sites of infections or injuries. This process involves cooperation between neutrophils where autocrine and paracrine positive-feedback loops, mediated by receptor/ligand pairs including lipid chemoattractants and chemokines, amplify localized recruitment of neutrophils. This review will provide an overview of key pathways involved in neutrophil swarming and then discuss the cell intrinsic and systemic mechanisms by which NADPH oxidase 2 (NOX2) regulates swarming, including modulation of calcium signaling, inflammatory mediators, and the mobilization and production of neutrophils. We will also discuss mechanisms by which altered neutrophil swarming in disease may contribute to deficient control of infections and/or exuberant inflammation. Deeper understanding of underlying mechanisms controlling neutrophil swarming and how neutrophil cooperative behavior can be perturbed in the setting of disease may help to guide development of tools for diagnosis and precision medicine.
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spelling pubmed-105794372023-10-18 Molecular regulation of neutrophil swarming in health and disease: Lessons from the phagocyte oxidase Song, Zhimin Bhattacharya, Sourav Clemens, Regina A. Dinauer, Mary C. iScience Review Neutrophil swarming is a complex coordinated process in which neutrophils sensing pathogen or damage signals are rapidly recruited to sites of infections or injuries. This process involves cooperation between neutrophils where autocrine and paracrine positive-feedback loops, mediated by receptor/ligand pairs including lipid chemoattractants and chemokines, amplify localized recruitment of neutrophils. This review will provide an overview of key pathways involved in neutrophil swarming and then discuss the cell intrinsic and systemic mechanisms by which NADPH oxidase 2 (NOX2) regulates swarming, including modulation of calcium signaling, inflammatory mediators, and the mobilization and production of neutrophils. We will also discuss mechanisms by which altered neutrophil swarming in disease may contribute to deficient control of infections and/or exuberant inflammation. Deeper understanding of underlying mechanisms controlling neutrophil swarming and how neutrophil cooperative behavior can be perturbed in the setting of disease may help to guide development of tools for diagnosis and precision medicine. Elsevier 2023-09-26 /pmc/articles/PMC10579437/ /pubmed/37854699 http://dx.doi.org/10.1016/j.isci.2023.108034 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Song, Zhimin
Bhattacharya, Sourav
Clemens, Regina A.
Dinauer, Mary C.
Molecular regulation of neutrophil swarming in health and disease: Lessons from the phagocyte oxidase
title Molecular regulation of neutrophil swarming in health and disease: Lessons from the phagocyte oxidase
title_full Molecular regulation of neutrophil swarming in health and disease: Lessons from the phagocyte oxidase
title_fullStr Molecular regulation of neutrophil swarming in health and disease: Lessons from the phagocyte oxidase
title_full_unstemmed Molecular regulation of neutrophil swarming in health and disease: Lessons from the phagocyte oxidase
title_short Molecular regulation of neutrophil swarming in health and disease: Lessons from the phagocyte oxidase
title_sort molecular regulation of neutrophil swarming in health and disease: lessons from the phagocyte oxidase
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579437/
https://www.ncbi.nlm.nih.gov/pubmed/37854699
http://dx.doi.org/10.1016/j.isci.2023.108034
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