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Association between Family History and Male Androgenetic Alopecia with Female Pattern Hair Loss

BACKGROUND: Male androgenetic alopecia (MAGA) is often accompanied by female pattern hair loss (FPHL). However, the risk factors related to MAGA with FPHL are unclear. OBJECTIVE: To investigate demographic and laboratory factors related to MAGA with FPHL. METHODS: This retrospective case-control stu...

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Autores principales: Lee, Sang-Hoon, Kang, Hyun, Lee, Won-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Dermatological Association; The Korean Society for Investigative Dermatology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579574/
https://www.ncbi.nlm.nih.gov/pubmed/37830416
http://dx.doi.org/10.5021/ad.22.221
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author Lee, Sang-Hoon
Kang, Hyun
Lee, Won-Soo
author_facet Lee, Sang-Hoon
Kang, Hyun
Lee, Won-Soo
author_sort Lee, Sang-Hoon
collection PubMed
description BACKGROUND: Male androgenetic alopecia (MAGA) is often accompanied by female pattern hair loss (FPHL). However, the risk factors related to MAGA with FPHL are unclear. OBJECTIVE: To investigate demographic and laboratory factors related to MAGA with FPHL. METHODS: This retrospective case-control study was performed in a single tertiary care center for MAGA with FPHL between March 2012 and September 2021. Eligible patients were males >12 years old diagnosed with androgenetic alopecia by a dermatologist. The patients were subdivided into MAGA with FPHL and MAGA without FPHL groups. Comorbidities as well as demographic, laboratory, and disease-specific variables were compared between the two groups. Data analysis was conducted between October 2021 and February 2022. The independent samples t-test, Mann–Whitney U test, and chi-squared test were used to assess the factors that contributed to MAGA with FPHL. RESULTS: Of 469 patients with MAGA, 309 (65.9%) had FPHL, which was a much higher rate than previously reported. Among the variables, only matrilineal (odds ratio, 1.605; 95% confidence interval, 1.014~2.541) and maternal history (odds ratio, 4.705; confidence interval, 1.632~13.559) of androgenetic alopecia were significantly associated with MAGA with FPHL. In the MAGA with FPHL group, a significant positive correlation was noted between body mass index and the type F score (r=0.114, p=0.025). CONCLUSION: In this case-control study, patients with MAGA and a maternal history of androgenetic alopecia were at risk of FPHL. Therefore, early screening may benefit these patients.
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spelling pubmed-105795742023-10-18 Association between Family History and Male Androgenetic Alopecia with Female Pattern Hair Loss Lee, Sang-Hoon Kang, Hyun Lee, Won-Soo Ann Dermatol Original Article BACKGROUND: Male androgenetic alopecia (MAGA) is often accompanied by female pattern hair loss (FPHL). However, the risk factors related to MAGA with FPHL are unclear. OBJECTIVE: To investigate demographic and laboratory factors related to MAGA with FPHL. METHODS: This retrospective case-control study was performed in a single tertiary care center for MAGA with FPHL between March 2012 and September 2021. Eligible patients were males >12 years old diagnosed with androgenetic alopecia by a dermatologist. The patients were subdivided into MAGA with FPHL and MAGA without FPHL groups. Comorbidities as well as demographic, laboratory, and disease-specific variables were compared between the two groups. Data analysis was conducted between October 2021 and February 2022. The independent samples t-test, Mann–Whitney U test, and chi-squared test were used to assess the factors that contributed to MAGA with FPHL. RESULTS: Of 469 patients with MAGA, 309 (65.9%) had FPHL, which was a much higher rate than previously reported. Among the variables, only matrilineal (odds ratio, 1.605; 95% confidence interval, 1.014~2.541) and maternal history (odds ratio, 4.705; confidence interval, 1.632~13.559) of androgenetic alopecia were significantly associated with MAGA with FPHL. In the MAGA with FPHL group, a significant positive correlation was noted between body mass index and the type F score (r=0.114, p=0.025). CONCLUSION: In this case-control study, patients with MAGA and a maternal history of androgenetic alopecia were at risk of FPHL. Therefore, early screening may benefit these patients. The Korean Dermatological Association; The Korean Society for Investigative Dermatology 2023-10 2023-09-22 /pmc/articles/PMC10579574/ /pubmed/37830416 http://dx.doi.org/10.5021/ad.22.221 Text en Copyright © The Korean Dermatological Association and The Korean Society for Investigative Dermatology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Sang-Hoon
Kang, Hyun
Lee, Won-Soo
Association between Family History and Male Androgenetic Alopecia with Female Pattern Hair Loss
title Association between Family History and Male Androgenetic Alopecia with Female Pattern Hair Loss
title_full Association between Family History and Male Androgenetic Alopecia with Female Pattern Hair Loss
title_fullStr Association between Family History and Male Androgenetic Alopecia with Female Pattern Hair Loss
title_full_unstemmed Association between Family History and Male Androgenetic Alopecia with Female Pattern Hair Loss
title_short Association between Family History and Male Androgenetic Alopecia with Female Pattern Hair Loss
title_sort association between family history and male androgenetic alopecia with female pattern hair loss
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579574/
https://www.ncbi.nlm.nih.gov/pubmed/37830416
http://dx.doi.org/10.5021/ad.22.221
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