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Impact of Previous Conventional Cardiac Surgery on the Clinical Outcomes After Heart Transplantation

The impact of the type, purpose, and timing of prior surgery on heart transplantation (HT) remains unclear. This study investigated the influence of conventional cardiac surgery (PCCS) on HT outcomes. This study analyzed HTs performed between 1999 and 2019 at a single institution. Patients were cate...

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Autores principales: Chen, Jeng-Wei, Chou, Heng-Wen, Chou, Nai-Kuan, Wang, Chih-Hsien, Chi, Nai-Hsin, Huang, Shu-Chien, Yu, Hsi-Yu, Chen, Yih-Sharng, Hsu, Ron-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579607/
https://www.ncbi.nlm.nih.gov/pubmed/37854464
http://dx.doi.org/10.3389/ti.2023.11824
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author Chen, Jeng-Wei
Chou, Heng-Wen
Chou, Nai-Kuan
Wang, Chih-Hsien
Chi, Nai-Hsin
Huang, Shu-Chien
Yu, Hsi-Yu
Chen, Yih-Sharng
Hsu, Ron-Bin
author_facet Chen, Jeng-Wei
Chou, Heng-Wen
Chou, Nai-Kuan
Wang, Chih-Hsien
Chi, Nai-Hsin
Huang, Shu-Chien
Yu, Hsi-Yu
Chen, Yih-Sharng
Hsu, Ron-Bin
author_sort Chen, Jeng-Wei
collection PubMed
description The impact of the type, purpose, and timing of prior surgery on heart transplantation (HT) remains unclear. This study investigated the influence of conventional cardiac surgery (PCCS) on HT outcomes. This study analyzed HTs performed between 1999 and 2019 at a single institution. Patients were categorized into two groups: those with and without PCCS. Short-term outcomes, including post-transplant complications and mortality rates, were evaluated. Cox proportional and Kaplan–Meier survival analyses were used to identify risk factors for mortality and assess long-term survival, respectively. Of 368 patients, 29% had PCCS. Patients with PCCS had a higher incidence of post-transplant complications. The in-hospital and 1 year mortality rates were higher in the PCCS group. PCCS and cardiopulmonary bypass time were significant risk factors for 1 year mortality (hazard ratios = 2.485 and 1.005, respectively). The long-term survival rates were lower in the PCCS group, particularly in the first year. In sub-analysis, patients with ischemic cardiomyopathy and PCCS had the poorest outcomes. The era of surgery and timing of PCCS in relation to HT did not significantly impact outcomes. In conclusion, PCCS worsen the HT outcomes, especially in patients with ischemic etiology. However, the timing of PCCS and era of HT did not significantly affect this concern.
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spelling pubmed-105796072023-10-18 Impact of Previous Conventional Cardiac Surgery on the Clinical Outcomes After Heart Transplantation Chen, Jeng-Wei Chou, Heng-Wen Chou, Nai-Kuan Wang, Chih-Hsien Chi, Nai-Hsin Huang, Shu-Chien Yu, Hsi-Yu Chen, Yih-Sharng Hsu, Ron-Bin Transpl Int Health Archive The impact of the type, purpose, and timing of prior surgery on heart transplantation (HT) remains unclear. This study investigated the influence of conventional cardiac surgery (PCCS) on HT outcomes. This study analyzed HTs performed between 1999 and 2019 at a single institution. Patients were categorized into two groups: those with and without PCCS. Short-term outcomes, including post-transplant complications and mortality rates, were evaluated. Cox proportional and Kaplan–Meier survival analyses were used to identify risk factors for mortality and assess long-term survival, respectively. Of 368 patients, 29% had PCCS. Patients with PCCS had a higher incidence of post-transplant complications. The in-hospital and 1 year mortality rates were higher in the PCCS group. PCCS and cardiopulmonary bypass time were significant risk factors for 1 year mortality (hazard ratios = 2.485 and 1.005, respectively). The long-term survival rates were lower in the PCCS group, particularly in the first year. In sub-analysis, patients with ischemic cardiomyopathy and PCCS had the poorest outcomes. The era of surgery and timing of PCCS in relation to HT did not significantly impact outcomes. In conclusion, PCCS worsen the HT outcomes, especially in patients with ischemic etiology. However, the timing of PCCS and era of HT did not significantly affect this concern. Frontiers Media S.A. 2023-10-03 /pmc/articles/PMC10579607/ /pubmed/37854464 http://dx.doi.org/10.3389/ti.2023.11824 Text en Copyright © 2023 Chen, Chou, Chou, Wang, Chi, Huang, Yu, Chen and Hsu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Health Archive
Chen, Jeng-Wei
Chou, Heng-Wen
Chou, Nai-Kuan
Wang, Chih-Hsien
Chi, Nai-Hsin
Huang, Shu-Chien
Yu, Hsi-Yu
Chen, Yih-Sharng
Hsu, Ron-Bin
Impact of Previous Conventional Cardiac Surgery on the Clinical Outcomes After Heart Transplantation
title Impact of Previous Conventional Cardiac Surgery on the Clinical Outcomes After Heart Transplantation
title_full Impact of Previous Conventional Cardiac Surgery on the Clinical Outcomes After Heart Transplantation
title_fullStr Impact of Previous Conventional Cardiac Surgery on the Clinical Outcomes After Heart Transplantation
title_full_unstemmed Impact of Previous Conventional Cardiac Surgery on the Clinical Outcomes After Heart Transplantation
title_short Impact of Previous Conventional Cardiac Surgery on the Clinical Outcomes After Heart Transplantation
title_sort impact of previous conventional cardiac surgery on the clinical outcomes after heart transplantation
topic Health Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579607/
https://www.ncbi.nlm.nih.gov/pubmed/37854464
http://dx.doi.org/10.3389/ti.2023.11824
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