Cargando…

Identification of an APOE ε4–specific blood‐based molecular pathway for Alzheimer's disease risk

INTRODUCTION: The precise apolipoprotein E (APOE) ε4‐specific molecular pathway(s) for Alzheimer's disease (AD) risk are unclear. METHODS: Plasma protein modules/cascades were analyzed using weighted gene co‐expression network analysis (WGCNA) in the Alzheimer's Disease Neuroimaging Initia...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tao, Qiushan, Zhang, Chao, Mercier, Gustavo, Lunetta, Kathryn, Ang, Ting Fang Alvin, Akhter‐Khan, Samia, Zhang, Zhengrong, Taylor, Andrew, Killiany, Ronald J., Alosco, Michael, Mez, Jesse, Au, Rhoda, Zhang, Xiaoling, Farrer, Lindsay A., Qiu, Wendy Wei Qiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579631/ https://www.ncbi.nlm.nih.gov/pubmed/37854772 http://dx.doi.org/10.1002/dad2.12490

Ejemplares similares

Different loneliness types, cognitive function, and brain structure in midlife: Findings from the Framingham Heart Study
por: Tao, Qiushan, et al.
Publicado: (2022)

The impact of blood MCP-1 levels on Alzheimer’s disease with genetic variation of UNC5C and NAV3 loci
por: Huang, Jinghan, et al.
Publicado: (2023)

Midlife lipid and glucose levels are associated with Alzheimer's disease
por: Zhang, Xiaoling, et al.
Publicado: (2022)

The impact of increasing levels of blood C-reactive protein on the inflammatory loci SPI1 and CD33 in Alzheimer’s disease
por: Huang, Jinghan, et al.
Publicado: (2022)

Association of Chronic Low-grade Inflammation With Risk of Alzheimer Disease in ApoE4 Carriers
por: Tao, Qiushan, et al.
Publicado: (2018)

Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease
por: Panitch, Rebecca, et al.
Publicado: (2021)

Association of Blood Cell Parameters of Peripheral Inflammation With Brain Imaging Measures
por: Fang, Yuan, et al.
Publicado: (2021)

Association of Blood Cell Parameters of Peripheral Inflammation With Brain Imaging Measures
por: Fang, Yuan, et al.
Publicado: (2021)

Alzheimer's disease genetic risk variants beyond APOE ε4 predict mortality
por: Mez, Jesse, et al.
Publicado: (2017)

Association of APOE Serum Levels and APOE ε2, ε3, and ε4 Alleles with Optic Neuritis
por: Momkute, Liucija, et al.
Publicado: (2022)

Hippocampal Resting-State Functional Connectivity Patterns are More Closely Associated with Severity of Subjective Memory Decline than Whole Hippocampal and Subfield Volumes
por: Zajac, Lauren, et al.
Publicado: (2020)

Why Loneliness Interventions Are Unsuccessful: A Call for Precision Health
por: Akhter-Khan, Samia C., et al.
Publicado: (2020)

APOE Promoter Polymorphism-219T/G is an Effect Modifier of the Influence of APOE ε4 on Alzheimer’s Disease Risk in a Multiracial Sample
por: Choi, Kyu Yeong, et al.
Publicado: (2019)

ε2 allele and ε2-involved genotypes (ε2/ε2, ε2/ε3, and ε2/ε4) may confer the association of APOE genetic polymorphism with risks of nephropathy in type 2 diabetes: a meta-analysis
por: Shi, Jikang, et al.
Publicado: (2020)

Association of Plasma Amylin Concentration With Alzheimer Disease and Brain Structure in Older Adults
por: Zhu, Haihao, et al.
Publicado: (2019)

Temporal association of neuropsychological test performance using unsupervised learning reveals a distinct signature of Alzheimer's disease status
por: Joshi, Prajakta S., et al.
Publicado: (2019)

Association between inflammatory biomarkers and cognitive aging
por: Fang, Yuan, et al.
Publicado: (2022)

Correction for: Circulating immune cell phenotypes are associated with age, sex, CMV, and smoking status in the Framingham Heart Study offspring participants
por: Fang, Yuan, et al.
Publicado: (2023)

Circulating immune cell phenotypes are associated with age, sex, CMV, and smoking status in the Framingham Heart Study offspring participants
por: Fang, Yuan, et al.
Publicado: (2023)

Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles
por: Walker, Rosie M., et al.
Publicado: (2021)

Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism
por: Nielsen, Henrietta M., et al.
Publicado: (2017)

Set-Based Rare Variant Expression Quantitative Trait Loci in Blood and Brain from Alzheimer Disease Study Participants
por: Patel, Devanshi, et al.
Publicado: (2021)

Updated meta-analysis of the role of APOE ε2/ε3/ε4 alleles in frontotemporal lobar degeneration
por: Su, Wen-Hua, et al.
Publicado: (2017)

Sex and APOE: A memory advantage in male APOE ε4 carriers in midlife
por: Zokaei, Nahid, et al.
Publicado: (2017)

Behavioral testing affects the phenotypic expression of APOE ε3 and APOE ε4 in targeted replacement mice and reduces the differences between them
por: Salomon-Zimri, Shiran, et al.
Publicado: (2015)

Anxiety correlates with cortical surface area in subjective cognitive decline: APOE ε4 carriers versus APOE ε4 non-carriers
por: Sun, Yu, et al.
Publicado: (2019)

Differences in resting-state brain networks and gray matter between APOE ε2 and APOE ε4 carriers in non-dementia elderly
por: Wang, Zhiyuan, et al.
Publicado: (2023)

Association of APOE Genotypes and Chronic Traumatic Encephalopathy
por: Atherton, Kathryn, et al.
Publicado: (2022)

Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease
por: Jun, Gyungah R., et al.
Publicado: (2022)

Alzheimer’s disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR‐edited human neuronal cells
por: You, Yang, et al.
Publicado: (2022)

Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia
por: Salvadó, Gemma, et al.
Publicado: (2021)

Associations of the APOE ε2 and ε4 alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer’s disease biomarkers
por: Kulminski, Alexander M., et al.
Publicado: (2022)

Monomeric C‐reactive protein via endothelial CD31 for neurovascular inflammation in an ApoE genotype‐dependent pattern: A risk factor for Alzheimer’s disease?
por: Zhang, Zhengrong, et al.
Publicado: (2021)

Peripheral inflammatory biomarkers are associated with cognitive function and dementia: Framingham Heart Study Offspring cohort
por: Chen, Jiachen, et al.
Publicado: (2023)

Symptomatic amyloid‐related imaging abnormalities in an APOE ε4/ε4 patient treated with aducanumab
por: VandeVrede, Lawren, et al.
Publicado: (2020)

The APOE(ε3/ε4) Genotype Drives Distinct Gene Signatures in the Cortex of Young Mice
por: Foley, Kate E., et al.
Publicado: (2022)

Association of APOE ε4/ε4 with fluid biomarkers in patients from the PUMCH dementia cohort
por: Shang, Li, et al.
Publicado: (2023)

APOEε4 and slow wave sleep in older adults
por: Tranah, Gregory J., et al.
Publicado: (2018)

Is APOE ε4 associated with cognitive performance in early MS?
por: Engel, Sinah, et al.
Publicado: (2020)

THE RELATIONSHIP OF APOE ε4 TO THE RELATIVE TIMES AND HAZARDS OF DEMENTIA
por: Powell, Danielle, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_753bp6v631fvv2r51mvos7ia9a