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Case Report: Successful treatment with methotrexate in a 10-year-old boy with co-occurrence of generalized psoriasis and vitiligo

The co-occurrence of psoriasis (PsO) and vitiligo is rare in Asian countries, especially in children. This case report presents the first-ever occurrence of PsO combined with vitiligo in an Asian boy under 6 years of age, in whom symptom improvement was observed after the use of methotrexate (MTX) a...

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Autores principales: Leong, Pui-Ying, Chiu, Tsu-Man, Wei, James Cheng-Chung, Huo, An-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579904/
https://www.ncbi.nlm.nih.gov/pubmed/37854600
http://dx.doi.org/10.3389/fimmu.2023.1255909
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author Leong, Pui-Ying
Chiu, Tsu-Man
Wei, James Cheng-Chung
Huo, An-Ping
author_facet Leong, Pui-Ying
Chiu, Tsu-Man
Wei, James Cheng-Chung
Huo, An-Ping
author_sort Leong, Pui-Ying
collection PubMed
description The co-occurrence of psoriasis (PsO) and vitiligo is rare in Asian countries, especially in children. This case report presents the first-ever occurrence of PsO combined with vitiligo in an Asian boy under 6 years of age, in whom symptom improvement was observed after the use of methotrexate (MTX) as the sole treatment. Although previous studies have indicated that there is a close correlation between the two diseases, methotrexate (MTX), which is a commonly used treatment for PsO, is not a standard treatment for vitiligo. Even with advanced progress in biologics and Janus kinase inhibitor (JAKi), the biologics and JAKi used in vitiligo are still inconsistent. In our case report, the successful use of MTX indicated that there are shared immune pathways between PsO and vitiligo. Further exploration is needed to optimize the treatment options for this co-occurrence of PsO and vitiligo.
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spelling pubmed-105799042023-10-18 Case Report: Successful treatment with methotrexate in a 10-year-old boy with co-occurrence of generalized psoriasis and vitiligo Leong, Pui-Ying Chiu, Tsu-Man Wei, James Cheng-Chung Huo, An-Ping Front Immunol Immunology The co-occurrence of psoriasis (PsO) and vitiligo is rare in Asian countries, especially in children. This case report presents the first-ever occurrence of PsO combined with vitiligo in an Asian boy under 6 years of age, in whom symptom improvement was observed after the use of methotrexate (MTX) as the sole treatment. Although previous studies have indicated that there is a close correlation between the two diseases, methotrexate (MTX), which is a commonly used treatment for PsO, is not a standard treatment for vitiligo. Even with advanced progress in biologics and Janus kinase inhibitor (JAKi), the biologics and JAKi used in vitiligo are still inconsistent. In our case report, the successful use of MTX indicated that there are shared immune pathways between PsO and vitiligo. Further exploration is needed to optimize the treatment options for this co-occurrence of PsO and vitiligo. Frontiers Media S.A. 2023-10-03 /pmc/articles/PMC10579904/ /pubmed/37854600 http://dx.doi.org/10.3389/fimmu.2023.1255909 Text en Copyright © 2023 Leong, Chiu, Wei and Huo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Leong, Pui-Ying
Chiu, Tsu-Man
Wei, James Cheng-Chung
Huo, An-Ping
Case Report: Successful treatment with methotrexate in a 10-year-old boy with co-occurrence of generalized psoriasis and vitiligo
title Case Report: Successful treatment with methotrexate in a 10-year-old boy with co-occurrence of generalized psoriasis and vitiligo
title_full Case Report: Successful treatment with methotrexate in a 10-year-old boy with co-occurrence of generalized psoriasis and vitiligo
title_fullStr Case Report: Successful treatment with methotrexate in a 10-year-old boy with co-occurrence of generalized psoriasis and vitiligo
title_full_unstemmed Case Report: Successful treatment with methotrexate in a 10-year-old boy with co-occurrence of generalized psoriasis and vitiligo
title_short Case Report: Successful treatment with methotrexate in a 10-year-old boy with co-occurrence of generalized psoriasis and vitiligo
title_sort case report: successful treatment with methotrexate in a 10-year-old boy with co-occurrence of generalized psoriasis and vitiligo
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579904/
https://www.ncbi.nlm.nih.gov/pubmed/37854600
http://dx.doi.org/10.3389/fimmu.2023.1255909
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