SRF617 Is a Potent Inhibitor of CD39 with Immunomodulatory and Antitumor Properties

CD39 (ENTPD1) is a key enzyme responsible for degradation of extracellular ATP and is upregulated in the tumor microenvironment (TME). Extracellular ATP accumulates in the TME from tissue damage and immunogenic cell death, potentially initiating proinflammatory responses that are reduced by the enzy...

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Detalles Bibliográficos
Autores principales: Warren, Michael C., Matissek, Stephan, Rausch, Matthew, Panduro, Marisella, Hall, Richard J., Dulak, Austin, Brennan, David, Yekkirala, Sonia Das, Koseoglu, Secil, Masia, Ricard, Yang, Yu, Reddy, Navamallika, Prenovitz, Robert, Strand, Jamie, Zaidi, Tauqueer, Devereaux, Erik, Foissac, Célia Jacoberger, Stagg, John, Lee, Benjamin H., Holland, Pamela, Palombella, Vito J., Lake, Andrew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2023
Materias:
Clinical and Translational Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579980/
https://www.ncbi.nlm.nih.gov/pubmed/37219538
http://dx.doi.org/10.4049/immunohorizons.2200089

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