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Five-years post commercial approval monitoring of eucalyptus H421

Eucalyptus comprises the largest planted area of cultivated production forest in Brazil. Genetic modification of eucalyptus can provide additional characteristics for increasing productivity, protecting plant yield, and potentially altering fiber for various industrial uses. With this objective, a t...

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Autores principales: Pinheiro, Ana Cristina, dos Santos, Anselmo Azevedo, Avisar, Dror, Gonsalves, José Mateus, Galan, Maria Paula, Abramson, Miron, Barimboim, Noga, Abrahão, Othon, Graça, Rodrigo Neves, Drezza, Thaís Regina, Silva, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580069/
https://www.ncbi.nlm.nih.gov/pubmed/37854879
http://dx.doi.org/10.3389/fbioe.2023.1257576
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author Pinheiro, Ana Cristina
dos Santos, Anselmo Azevedo
Avisar, Dror
Gonsalves, José Mateus
Galan, Maria Paula
Abramson, Miron
Barimboim, Noga
Abrahão, Othon
Graça, Rodrigo Neves
Drezza, Thaís Regina
Silva, William
author_facet Pinheiro, Ana Cristina
dos Santos, Anselmo Azevedo
Avisar, Dror
Gonsalves, José Mateus
Galan, Maria Paula
Abramson, Miron
Barimboim, Noga
Abrahão, Othon
Graça, Rodrigo Neves
Drezza, Thaís Regina
Silva, William
author_sort Pinheiro, Ana Cristina
collection PubMed
description Eucalyptus comprises the largest planted area of cultivated production forest in Brazil. Genetic modification of eucalyptus can provide additional characteristics for increasing productivity, protecting plant yield, and potentially altering fiber for various industrial uses. With this objective, a transgenic eucalyptus variety, event H421, received regulatory approval for commercial release after 6 years of approved risk assessment studies by the Brazilian National Technical Biosafety Commission (CTNBio) in 2015, becoming the first approved genetically modified (GM) eucalyptus in the world. GM event H421 enables increased plant biomass accumulation through overexpression of the Arabidopsis 1,4-β-endoglucanase Cel1, which remodels the xyloglucan–cellulose matrix of the cell wall during development to promote cell expansion and growth. As required, in that time, by the current normative from CTNBio, a post-commercial release monitoring plan for H421 was submitted, incorporating general surveillance for five consecutive years with the submission of annual reports. The monitoring plan was conducted on fields of H421 progenies, with conventional clones as comparators, cultivated in representative regions where eucalyptus is cultivated in the states of São Paulo, Bahia, and Maranhão, representing Southeast, Northeast, and Northern Brazil. Over the course of the five-year general surveillance monitoring plan for the approved GM eucalyptus H421, no adverse effect that could impact the biosafety of the commercially approved event was identified. Additionally, the GM eucalyptus exhibited behavior highly consistent with that of conventional commercial clones. Therefore, there was no need for an extra risk assessment study of a case-specific monitoring plan. The results show the importance of continuously updating the regulation norms of governmental agencies to align with scientific advances.
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spelling pubmed-105800692023-10-18 Five-years post commercial approval monitoring of eucalyptus H421 Pinheiro, Ana Cristina dos Santos, Anselmo Azevedo Avisar, Dror Gonsalves, José Mateus Galan, Maria Paula Abramson, Miron Barimboim, Noga Abrahão, Othon Graça, Rodrigo Neves Drezza, Thaís Regina Silva, William Front Bioeng Biotechnol Bioengineering and Biotechnology Eucalyptus comprises the largest planted area of cultivated production forest in Brazil. Genetic modification of eucalyptus can provide additional characteristics for increasing productivity, protecting plant yield, and potentially altering fiber for various industrial uses. With this objective, a transgenic eucalyptus variety, event H421, received regulatory approval for commercial release after 6 years of approved risk assessment studies by the Brazilian National Technical Biosafety Commission (CTNBio) in 2015, becoming the first approved genetically modified (GM) eucalyptus in the world. GM event H421 enables increased plant biomass accumulation through overexpression of the Arabidopsis 1,4-β-endoglucanase Cel1, which remodels the xyloglucan–cellulose matrix of the cell wall during development to promote cell expansion and growth. As required, in that time, by the current normative from CTNBio, a post-commercial release monitoring plan for H421 was submitted, incorporating general surveillance for five consecutive years with the submission of annual reports. The monitoring plan was conducted on fields of H421 progenies, with conventional clones as comparators, cultivated in representative regions where eucalyptus is cultivated in the states of São Paulo, Bahia, and Maranhão, representing Southeast, Northeast, and Northern Brazil. Over the course of the five-year general surveillance monitoring plan for the approved GM eucalyptus H421, no adverse effect that could impact the biosafety of the commercially approved event was identified. Additionally, the GM eucalyptus exhibited behavior highly consistent with that of conventional commercial clones. Therefore, there was no need for an extra risk assessment study of a case-specific monitoring plan. The results show the importance of continuously updating the regulation norms of governmental agencies to align with scientific advances. Frontiers Media S.A. 2023-10-03 /pmc/articles/PMC10580069/ /pubmed/37854879 http://dx.doi.org/10.3389/fbioe.2023.1257576 Text en Copyright © 2023 Pinheiro, dos Santos, Avisar, Gonsalves, Galan, Abramson, Barimboim, Abrahão, Graça, Drezza and Silva. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Pinheiro, Ana Cristina
dos Santos, Anselmo Azevedo
Avisar, Dror
Gonsalves, José Mateus
Galan, Maria Paula
Abramson, Miron
Barimboim, Noga
Abrahão, Othon
Graça, Rodrigo Neves
Drezza, Thaís Regina
Silva, William
Five-years post commercial approval monitoring of eucalyptus H421
title Five-years post commercial approval monitoring of eucalyptus H421
title_full Five-years post commercial approval monitoring of eucalyptus H421
title_fullStr Five-years post commercial approval monitoring of eucalyptus H421
title_full_unstemmed Five-years post commercial approval monitoring of eucalyptus H421
title_short Five-years post commercial approval monitoring of eucalyptus H421
title_sort five-years post commercial approval monitoring of eucalyptus h421
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580069/
https://www.ncbi.nlm.nih.gov/pubmed/37854879
http://dx.doi.org/10.3389/fbioe.2023.1257576
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