Selective targeting of α7 nicotinic acetylcholine receptor by synthetic peptide mimicking loop I of human SLURP-1 provides efficient and prolonged therapy of epidermoid carcinoma in vivo

α7-Type nicotinic acetylcholine receptor (α7-nAChR) promotes the growth and metastasis of solid tumors. Secreted Ly6/uPAR-Related Protein 1 (SLURP-1) is a specific negative modulator of α7-nAChR produced by epithelial cells. Here, we investigated mechanisms of antiproliferative activity of recombina...

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Detalles Bibliográficos
Autores principales: Shlepova, O. V., Shulepko, M. A., Shipunova, V. O., Bychkov, M. L., Kukushkin, I. D., Chulina, I. A., Azev, V. N., Shramova, E. I., Kazakov, V. A., Ismailova, A. M., Palikova, Y. A., Palikov, V. A., Kalabina, E. A., Shaykhutdinova, E. A., Slashcheva, G. A., Tukhovskaya, E. A., Dyachenko, I. A., Murashev, A. N., Deyev, S. M., Kirpichnikov, M. P., Shenkarev, Z. O., Lyukmanova, E. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580074/
https://www.ncbi.nlm.nih.gov/pubmed/37854069
http://dx.doi.org/10.3389/fcell.2023.1256716

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