Multiple DNA repair pathways contribute to MMS-induced post-replicative DNA synthesis in S. pombe .

Replication stress can induce DNA synthesis outside of replicative S-phase. We have previously demonstrated that fission yeast cells stimulate DNA synthesis in G2-phase but not in M-phase in response to DNA alkylating agent MMS. In this study, we show that various DNA repair pathways, including tran...

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Detalles Bibliográficos
Autores principales: Kim, Seong Min, Forsburg, Susan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2023
Materias:
Data Updates
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580077/
https://www.ncbi.nlm.nih.gov/pubmed/37854101
http://dx.doi.org/10.17912/micropub.biology.000974
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author Kim, Seong Min
Forsburg, Susan L.
author_facet Kim, Seong Min
Forsburg, Susan L.
author_sort Kim, Seong Min
collection PubMed
description Replication stress can induce DNA synthesis outside of replicative S-phase. We have previously demonstrated that fission yeast cells stimulate DNA synthesis in G2-phase but not in M-phase in response to DNA alkylating agent MMS. In this study, we show that various DNA repair pathways, including translesion synthesis and break-induced replication contribute to post-replicative DNA synthesis. Checkpoint kinases, various repair and resection proteins, and multiple polymerases are also involved.
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spelling pubmed-105800772023-10-18 Multiple DNA repair pathways contribute to MMS-induced post-replicative DNA synthesis in S. pombe . Kim, Seong Min Forsburg, Susan L. MicroPubl Biol Data Updates Replication stress can induce DNA synthesis outside of replicative S-phase. We have previously demonstrated that fission yeast cells stimulate DNA synthesis in G2-phase but not in M-phase in response to DNA alkylating agent MMS. In this study, we show that various DNA repair pathways, including translesion synthesis and break-induced replication contribute to post-replicative DNA synthesis. Checkpoint kinases, various repair and resection proteins, and multiple polymerases are also involved. Caltech Library 2023-10-02 /pmc/articles/PMC10580077/ /pubmed/37854101 http://dx.doi.org/10.17912/micropub.biology.000974 Text en Copyright: © 2023 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Data Updates
Kim, Seong Min
Forsburg, Susan L.
Multiple DNA repair pathways contribute to MMS-induced post-replicative DNA synthesis in S. pombe .
title Multiple DNA repair pathways contribute to MMS-induced post-replicative DNA synthesis in S. pombe .
title_full Multiple DNA repair pathways contribute to MMS-induced post-replicative DNA synthesis in S. pombe .
title_fullStr Multiple DNA repair pathways contribute to MMS-induced post-replicative DNA synthesis in S. pombe .
title_full_unstemmed Multiple DNA repair pathways contribute to MMS-induced post-replicative DNA synthesis in S. pombe .
title_short Multiple DNA repair pathways contribute to MMS-induced post-replicative DNA synthesis in S. pombe .
title_sort multiple dna repair pathways contribute to mms-induced post-replicative dna synthesis in s. pombe .
topic Data Updates
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580077/
https://www.ncbi.nlm.nih.gov/pubmed/37854101
http://dx.doi.org/10.17912/micropub.biology.000974
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