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Human IL-35 Inhibits the Bioactivity of IL-12 and Its Interaction with IL-12Rβ2

IL-35 is an immunosuppressive cytokine with roles in cancer, autoimmunity, and infectious disease. In the conventional model of IL-35 biology, the p35 and Ebi3 domains of this cytokine interact with IL-12Rβ2 and gp130, respectively, on the cell surface of regulatory T and regulatory B cells, trigger...

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Detalles Bibliográficos
Autores principales:	Mahfooz, Najmus S., Merling, Marlena R., Claeys, Tiffany A., Dowling, Jack W., Forero, Adriana, Robinson, Richard T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AAI 2023
Materias:	Adaptive Immunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580122/ https://www.ncbi.nlm.nih.gov/pubmed/37289499 http://dx.doi.org/10.4049/immunohorizons.2300039

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