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Coinfection With Severe Fever With Thrombocytopenia Syndrome and Scrub Typhus in Korea
BACKGROUND: Scrub typhus and severe fever with thrombocytopenia syndrome (SFTS) are the 2 most common tick-borne infectious diseases in Korea. Every year, an increasing number of cases are reported, which is a public health concern. Therefore, we aimed to investigate the prevalence of SFTS–scrub typ...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580145/ https://www.ncbi.nlm.nih.gov/pubmed/37854108 http://dx.doi.org/10.1093/ofid/ofad377 |
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author | Chatterjee, Shilpa Kim, Choon-Me Kim, Dong-Min Seo, Jun-Won Kim, Da Young Yun, Na-Ra Jung, Sook In Kim, Uh Jin Kim, Seong Eun Kim, Hyun ah Kim, Eu Suk Hur, Jian Kim, Young Keun Jeong, Hye Won Heo, Jung Yeon Jung, Dong Sik Lee, Hyungdon Park, Sun Hee Kwak, Yee Gyung Lee, Sujin Chatterjee, Rajendra Prasad |
author_facet | Chatterjee, Shilpa Kim, Choon-Me Kim, Dong-Min Seo, Jun-Won Kim, Da Young Yun, Na-Ra Jung, Sook In Kim, Uh Jin Kim, Seong Eun Kim, Hyun ah Kim, Eu Suk Hur, Jian Kim, Young Keun Jeong, Hye Won Heo, Jung Yeon Jung, Dong Sik Lee, Hyungdon Park, Sun Hee Kwak, Yee Gyung Lee, Sujin Chatterjee, Rajendra Prasad |
author_sort | Chatterjee, Shilpa |
collection | PubMed |
description | BACKGROUND: Scrub typhus and severe fever with thrombocytopenia syndrome (SFTS) are the 2 most common tick-borne infectious diseases in Korea. Every year, an increasing number of cases are reported, which is a public health concern. Therefore, we aimed to investigate the prevalence of SFTS–scrub typhus coinfection in patients with SFTS. METHODS: Clinical samples were collected from 129 patients with SFTS. One-step reverse-transcription polymerase chain reaction (PCR) was performed to identify the SFTS virus (SFTSV), and real-time PCR followed by nested PCR was performed to detect the Orientia tsutsugamushi gene for scrub typhus. Phylogenetic analysis was conducted to confirm the evolutionary relationships among different species. RESULTS: Among 129 SFTS cases, 2 patients with SFTSV were positive for O. tsutsugamushi with a prevalence of coinfection of 1.6% (95% confidence interval, .001–.06). Phylogenetic analysis confirmed these as O. tsutsugamushi strain Boryong. CONCLUSIONS: Our study found that 1.6% of patients were coinfected with SFTS and scrub typhus infection. We believe that this information will add a new dimension to clinical diagnosis, which should be considered for better public health management. Further research is needed to better understand the ecological transmission dynamics and geographical distribution of SFTSV and O. tsutsugamushi in endemic countries. |
format | Online Article Text |
id | pubmed-10580145 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-105801452023-10-18 Coinfection With Severe Fever With Thrombocytopenia Syndrome and Scrub Typhus in Korea Chatterjee, Shilpa Kim, Choon-Me Kim, Dong-Min Seo, Jun-Won Kim, Da Young Yun, Na-Ra Jung, Sook In Kim, Uh Jin Kim, Seong Eun Kim, Hyun ah Kim, Eu Suk Hur, Jian Kim, Young Keun Jeong, Hye Won Heo, Jung Yeon Jung, Dong Sik Lee, Hyungdon Park, Sun Hee Kwak, Yee Gyung Lee, Sujin Chatterjee, Rajendra Prasad Open Forum Infect Dis Major Article BACKGROUND: Scrub typhus and severe fever with thrombocytopenia syndrome (SFTS) are the 2 most common tick-borne infectious diseases in Korea. Every year, an increasing number of cases are reported, which is a public health concern. Therefore, we aimed to investigate the prevalence of SFTS–scrub typhus coinfection in patients with SFTS. METHODS: Clinical samples were collected from 129 patients with SFTS. One-step reverse-transcription polymerase chain reaction (PCR) was performed to identify the SFTS virus (SFTSV), and real-time PCR followed by nested PCR was performed to detect the Orientia tsutsugamushi gene for scrub typhus. Phylogenetic analysis was conducted to confirm the evolutionary relationships among different species. RESULTS: Among 129 SFTS cases, 2 patients with SFTSV were positive for O. tsutsugamushi with a prevalence of coinfection of 1.6% (95% confidence interval, .001–.06). Phylogenetic analysis confirmed these as O. tsutsugamushi strain Boryong. CONCLUSIONS: Our study found that 1.6% of patients were coinfected with SFTS and scrub typhus infection. We believe that this information will add a new dimension to clinical diagnosis, which should be considered for better public health management. Further research is needed to better understand the ecological transmission dynamics and geographical distribution of SFTSV and O. tsutsugamushi in endemic countries. Oxford University Press 2023-10-17 /pmc/articles/PMC10580145/ /pubmed/37854108 http://dx.doi.org/10.1093/ofid/ofad377 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Major Article Chatterjee, Shilpa Kim, Choon-Me Kim, Dong-Min Seo, Jun-Won Kim, Da Young Yun, Na-Ra Jung, Sook In Kim, Uh Jin Kim, Seong Eun Kim, Hyun ah Kim, Eu Suk Hur, Jian Kim, Young Keun Jeong, Hye Won Heo, Jung Yeon Jung, Dong Sik Lee, Hyungdon Park, Sun Hee Kwak, Yee Gyung Lee, Sujin Chatterjee, Rajendra Prasad Coinfection With Severe Fever With Thrombocytopenia Syndrome and Scrub Typhus in Korea |
title | Coinfection With Severe Fever With Thrombocytopenia Syndrome and Scrub Typhus in Korea |
title_full | Coinfection With Severe Fever With Thrombocytopenia Syndrome and Scrub Typhus in Korea |
title_fullStr | Coinfection With Severe Fever With Thrombocytopenia Syndrome and Scrub Typhus in Korea |
title_full_unstemmed | Coinfection With Severe Fever With Thrombocytopenia Syndrome and Scrub Typhus in Korea |
title_short | Coinfection With Severe Fever With Thrombocytopenia Syndrome and Scrub Typhus in Korea |
title_sort | coinfection with severe fever with thrombocytopenia syndrome and scrub typhus in korea |
topic | Major Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580145/ https://www.ncbi.nlm.nih.gov/pubmed/37854108 http://dx.doi.org/10.1093/ofid/ofad377 |
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