A Chemoproteomic Approach to Elucidate the Mechanism of Action of 6-Azasteroids with Unique Activity in Mycobacteria

[Image: see text] By illuminating key 6-azasteroid–protein interactions in both Mycobacterium tuberculosis (Mtb) and the closely related model organism Mycobacterium marinum (Mm), we sought to improve the antimycobacterial potency of 6-azasteroids and further our understanding of the mechanisms resp...

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Detalles Bibliográficos
Autores principales: Werman, Joshua M., Chen, Yu-Ching, Yuan, Tianao, Yang, Xinxin, Sampson, Nicole S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580313/
https://www.ncbi.nlm.nih.gov/pubmed/37774412
http://dx.doi.org/10.1021/acsinfecdis.3c00296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580313/
https://www.ncbi.nlm.nih.gov/pubmed/37774412
http://dx.doi.org/10.1021/acsinfecdis.3c00296

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