Upregulation of lysine‐specific demethylase 6B aggravates inflammatory pain through H3K27me3 demethylation‐dependent production of TNF‐α in the dorsal root ganglia and spinal dorsal horn in rats

AIMS: Lysine‐specific demethylase 6B (KDM6B) serves as a key mediator of gene transcription. It regulates expression of proinflammatory cytokines and chemokines in variety of diseases. Herein, the role and the underlying mechanisms of KDM6B in inflammatory pain were studied. METHODS: The inflammator...

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Detalles Bibliográficos
Autores principales: Qiao, Yiming, Li, Liren, Bai, Liying, Gao, Yan, Yang, Yin, Wang, Li, Wang, Xueli, Liang, Zongyi, Xu, Ji‐Tian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580362/
https://www.ncbi.nlm.nih.gov/pubmed/37287407
http://dx.doi.org/10.1111/cns.14281

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