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Nano‐delivery systems as a promising therapeutic potential for epilepsy: Current status and future perspectives

Epilepsy is a common chronic neurological disorder caused by aberrant neuronal electrical activity. Antiseizure medications (ASMs) are the first line of treatment for people with epilepsy (PWE). However, their effectiveness may be limited by their inability to cross the blood–brain barrier (BBB), am...

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Detalles Bibliográficos
Autores principales: Movahedpour, Ahmad, Taghvaeefar, Rasul, Asadi‐Pooya, Ali‐Akbar, Karami, Yousof, Tavasolian, Ronia, Khatami, Seyyed Hossein, Soltani Fard, Elahe, Taghvimi, Sina, Karami, Neda, Rahimi Jaberi, Khojaste, Taheri‐Anganeh, Mortaza, Ghasemi, Hassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580365/
https://www.ncbi.nlm.nih.gov/pubmed/37452477
http://dx.doi.org/10.1111/cns.14355
Descripción
Sumario:Epilepsy is a common chronic neurological disorder caused by aberrant neuronal electrical activity. Antiseizure medications (ASMs) are the first line of treatment for people with epilepsy (PWE). However, their effectiveness may be limited by their inability to cross the blood–brain barrier (BBB), among many other potential underpinnings for drug resistance in epilepsy. Therefore, there is a need to overcome this issue and, hopefully, improve the effectiveness of ASMs. Recently, synthetic nanoparticle‐based drug delivery systems have received attention for improving the effectiveness of ASMs due to their ability to cross the BBB. Furthermore, exosomes have emerged as a promising generation of drug delivery systems because of their potential benefits over synthetic nanoparticles. In this narrative review, we focus on various synthetic nanoparticles that have been studied to deliver ASMs. Furthermore, the benefits and limitations of each nano‐delivery system have been discussed. Finally, we discuss exosomes as potentially promising delivery tools for treating epilepsy.