Recurrent Hypoglycemia Secondary to Insulinoma in an Adult With Beckwith-Wiedemann Syndrome

Beckwith-Wiedemann syndrome (BWS) is a rare genetic disorder characterized by genetic and epigenetic changes on the chromosome 11p15.5 region, which includes genes that are important for fetal and postnatal growth. Children with BWS have a higher chance of having hypoglycemia, hyperinsulinemia, and...

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Autores principales: Akcan, Tugce, Shariff, Julia Rose R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580426/
https://www.ncbi.nlm.nih.gov/pubmed/37908580
http://dx.doi.org/10.1210/jcemcr/luad062
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author Akcan, Tugce
Shariff, Julia Rose R
author_facet Akcan, Tugce
Shariff, Julia Rose R
author_sort Akcan, Tugce
collection PubMed
description Beckwith-Wiedemann syndrome (BWS) is a rare genetic disorder characterized by genetic and epigenetic changes on the chromosome 11p15.5 region, which includes genes that are important for fetal and postnatal growth. Children with BWS have a higher chance of having hypoglycemia, hyperinsulinemia, and malignancies early in life, although hypoglycemia caused by an insulinoma that develops later in life has not been reported. We describe the diagnosis of insulinoma in a 53-year-old man with BWS in this case report. This is the first case report of insulinoma in an adult with this syndrome.
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spelling pubmed-105804262023-10-31 Recurrent Hypoglycemia Secondary to Insulinoma in an Adult With Beckwith-Wiedemann Syndrome Akcan, Tugce Shariff, Julia Rose R JCEM Case Rep Case Report Beckwith-Wiedemann syndrome (BWS) is a rare genetic disorder characterized by genetic and epigenetic changes on the chromosome 11p15.5 region, which includes genes that are important for fetal and postnatal growth. Children with BWS have a higher chance of having hypoglycemia, hyperinsulinemia, and malignancies early in life, although hypoglycemia caused by an insulinoma that develops later in life has not been reported. We describe the diagnosis of insulinoma in a 53-year-old man with BWS in this case report. This is the first case report of insulinoma in an adult with this syndrome. Oxford University Press 2023-06-28 /pmc/articles/PMC10580426/ /pubmed/37908580 http://dx.doi.org/10.1210/jcemcr/luad062 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Akcan, Tugce
Shariff, Julia Rose R
Recurrent Hypoglycemia Secondary to Insulinoma in an Adult With Beckwith-Wiedemann Syndrome
title Recurrent Hypoglycemia Secondary to Insulinoma in an Adult With Beckwith-Wiedemann Syndrome
title_full Recurrent Hypoglycemia Secondary to Insulinoma in an Adult With Beckwith-Wiedemann Syndrome
title_fullStr Recurrent Hypoglycemia Secondary to Insulinoma in an Adult With Beckwith-Wiedemann Syndrome
title_full_unstemmed Recurrent Hypoglycemia Secondary to Insulinoma in an Adult With Beckwith-Wiedemann Syndrome
title_short Recurrent Hypoglycemia Secondary to Insulinoma in an Adult With Beckwith-Wiedemann Syndrome
title_sort recurrent hypoglycemia secondary to insulinoma in an adult with beckwith-wiedemann syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580426/
https://www.ncbi.nlm.nih.gov/pubmed/37908580
http://dx.doi.org/10.1210/jcemcr/luad062
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AT shariffjuliaroser recurrenthypoglycemiasecondarytoinsulinomainanadultwithbeckwithwiedemannsyndrome

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