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A 36-Year-Old Woman With an Unexpected Cause of Hypokalemia

A 36-year-old woman complained of bilateral lower limb weakness for the last 3 days. She could move her upper limb, neck, and facial muscles and had no respiratory or swallowing difficulties. About 4 years ago, she complained of sudden weakness involving her lower limbs. Two years later, she had ano...

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Detalles Bibliográficos
Autores principales: Rao, Mohan K, Swarup, P Mirudhubashini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580493/
https://www.ncbi.nlm.nih.gov/pubmed/37908989
http://dx.doi.org/10.1210/jcemcr/luad060
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author Rao, Mohan K
Swarup, P Mirudhubashini
author_facet Rao, Mohan K
Swarup, P Mirudhubashini
author_sort Rao, Mohan K
collection PubMed
description A 36-year-old woman complained of bilateral lower limb weakness for the last 3 days. She could move her upper limb, neck, and facial muscles and had no respiratory or swallowing difficulties. About 4 years ago, she complained of sudden weakness involving her lower limbs. Two years later, she had another episode involving only the right upper limb. In both cases, she was hypokalemic and received oral and intravenous potassium. She is a known diabetic and has polycystic ovary disease. Her blood pressure was 150/100 mm Hg, and body mass index was 29. Her serum potassium was 2 mEq/L, plasma renin 5 ng/dL, plasma aldosterone 0.63 µIU/mL, and aldosterone to plasma renin activity ratio 8. Cushing syndrome was considered a possibility. Subsequent analysis indicated a baseline cortisol level of 19.6 µg/dL at 8 Am. A screening overnight 1-mg dexamethasone suppression test (DST) showed 17 µg/dL cortisol. The low-dose DST revealed a cortisol level of 10.8 µg/dL. Adrenocorticotropin level was 196 pg/mL, and 24-hour urinary cortisol level was 1284 mg/dL. A high dose of 8-mg DST at 11 Pm to find the source of hypercortisolism performed yielded 15.9 µg/dL. Magnetic resonance imaging of the pituitary displayed a well-defined, heterogeneously enhanced mass lesion (15 × 13 × 11 mm) in the sella with mild suprasellar extension. Transsphenoidal resection and stereotactic radiosurgery were performed on the tumor with hormone replacement and glycemic control following surgery.
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spelling pubmed-105804932023-10-31 A 36-Year-Old Woman With an Unexpected Cause of Hypokalemia Rao, Mohan K Swarup, P Mirudhubashini JCEM Case Rep Case Report A 36-year-old woman complained of bilateral lower limb weakness for the last 3 days. She could move her upper limb, neck, and facial muscles and had no respiratory or swallowing difficulties. About 4 years ago, she complained of sudden weakness involving her lower limbs. Two years later, she had another episode involving only the right upper limb. In both cases, she was hypokalemic and received oral and intravenous potassium. She is a known diabetic and has polycystic ovary disease. Her blood pressure was 150/100 mm Hg, and body mass index was 29. Her serum potassium was 2 mEq/L, plasma renin 5 ng/dL, plasma aldosterone 0.63 µIU/mL, and aldosterone to plasma renin activity ratio 8. Cushing syndrome was considered a possibility. Subsequent analysis indicated a baseline cortisol level of 19.6 µg/dL at 8 Am. A screening overnight 1-mg dexamethasone suppression test (DST) showed 17 µg/dL cortisol. The low-dose DST revealed a cortisol level of 10.8 µg/dL. Adrenocorticotropin level was 196 pg/mL, and 24-hour urinary cortisol level was 1284 mg/dL. A high dose of 8-mg DST at 11 Pm to find the source of hypercortisolism performed yielded 15.9 µg/dL. Magnetic resonance imaging of the pituitary displayed a well-defined, heterogeneously enhanced mass lesion (15 × 13 × 11 mm) in the sella with mild suprasellar extension. Transsphenoidal resection and stereotactic radiosurgery were performed on the tumor with hormone replacement and glycemic control following surgery. Oxford University Press 2023-08-24 /pmc/articles/PMC10580493/ /pubmed/37908989 http://dx.doi.org/10.1210/jcemcr/luad060 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Rao, Mohan K
Swarup, P Mirudhubashini
A 36-Year-Old Woman With an Unexpected Cause of Hypokalemia
title A 36-Year-Old Woman With an Unexpected Cause of Hypokalemia
title_full A 36-Year-Old Woman With an Unexpected Cause of Hypokalemia
title_fullStr A 36-Year-Old Woman With an Unexpected Cause of Hypokalemia
title_full_unstemmed A 36-Year-Old Woman With an Unexpected Cause of Hypokalemia
title_short A 36-Year-Old Woman With an Unexpected Cause of Hypokalemia
title_sort 36-year-old woman with an unexpected cause of hypokalemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580493/
https://www.ncbi.nlm.nih.gov/pubmed/37908989
http://dx.doi.org/10.1210/jcemcr/luad060
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