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Role of exosomes in the development, diagnosis, prognosis and treatment of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most common primary liver cancer. It is characterized by occult onset resulting in most patients being diagnosed at advanced stages and with poor prognosis. Exosomes are nanoscale vesicles with a lipid bilayer envelope released by various cells under physiologic...

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Autores principales: Liu, Meijin, Lai, Zhonghong, Yuan, Xiaoying, Jin, Qing, Shen, Haibin, Rao, Dingyu, Huang, Defa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580543/
https://www.ncbi.nlm.nih.gov/pubmed/37848835
http://dx.doi.org/10.1186/s10020-023-00731-5
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author Liu, Meijin
Lai, Zhonghong
Yuan, Xiaoying
Jin, Qing
Shen, Haibin
Rao, Dingyu
Huang, Defa
author_facet Liu, Meijin
Lai, Zhonghong
Yuan, Xiaoying
Jin, Qing
Shen, Haibin
Rao, Dingyu
Huang, Defa
author_sort Liu, Meijin
collection PubMed
description Hepatocellular carcinoma (HCC) is the most common primary liver cancer. It is characterized by occult onset resulting in most patients being diagnosed at advanced stages and with poor prognosis. Exosomes are nanoscale vesicles with a lipid bilayer envelope released by various cells under physiological and pathological conditions, which play an important role in the biological information transfer between cells. There is growing evidence that HCC cell-derived exosomes may contribute to the establishment of a favorable microenvironment that supports cancer cell proliferation, invasion, and metastasis. These exosomes not only provide a versatile platform for diagnosis but also serve as a vehicle for drug delivery. In this paper, we review the role of exosomes involved in the proliferation, migration, and metastasis of HCC and describe their application in HCC diagnosis and treatment. We also discuss the prospects of exosome application in HCC and the research challenges.
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spelling pubmed-105805432023-10-18 Role of exosomes in the development, diagnosis, prognosis and treatment of hepatocellular carcinoma Liu, Meijin Lai, Zhonghong Yuan, Xiaoying Jin, Qing Shen, Haibin Rao, Dingyu Huang, Defa Mol Med Review Hepatocellular carcinoma (HCC) is the most common primary liver cancer. It is characterized by occult onset resulting in most patients being diagnosed at advanced stages and with poor prognosis. Exosomes are nanoscale vesicles with a lipid bilayer envelope released by various cells under physiological and pathological conditions, which play an important role in the biological information transfer between cells. There is growing evidence that HCC cell-derived exosomes may contribute to the establishment of a favorable microenvironment that supports cancer cell proliferation, invasion, and metastasis. These exosomes not only provide a versatile platform for diagnosis but also serve as a vehicle for drug delivery. In this paper, we review the role of exosomes involved in the proliferation, migration, and metastasis of HCC and describe their application in HCC diagnosis and treatment. We also discuss the prospects of exosome application in HCC and the research challenges. BioMed Central 2023-10-17 /pmc/articles/PMC10580543/ /pubmed/37848835 http://dx.doi.org/10.1186/s10020-023-00731-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Liu, Meijin
Lai, Zhonghong
Yuan, Xiaoying
Jin, Qing
Shen, Haibin
Rao, Dingyu
Huang, Defa
Role of exosomes in the development, diagnosis, prognosis and treatment of hepatocellular carcinoma
title Role of exosomes in the development, diagnosis, prognosis and treatment of hepatocellular carcinoma
title_full Role of exosomes in the development, diagnosis, prognosis and treatment of hepatocellular carcinoma
title_fullStr Role of exosomes in the development, diagnosis, prognosis and treatment of hepatocellular carcinoma
title_full_unstemmed Role of exosomes in the development, diagnosis, prognosis and treatment of hepatocellular carcinoma
title_short Role of exosomes in the development, diagnosis, prognosis and treatment of hepatocellular carcinoma
title_sort role of exosomes in the development, diagnosis, prognosis and treatment of hepatocellular carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580543/
https://www.ncbi.nlm.nih.gov/pubmed/37848835
http://dx.doi.org/10.1186/s10020-023-00731-5
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