Senataxin helicase, the causal gene defect in ALS4, is a significant modifier of C9orf72 ALS G4C2 and arginine-containing dipeptide repeat toxicity

Identifying genetic modifiers of familial amyotrophic lateral sclerosis (ALS) may reveal targets for therapeutic modulation with potential application to sporadic ALS. GGGGCC (G4C2) repeat expansions in the C9orf72 gene underlie the most common form of familial ALS, and generate toxic arginine-conta...

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Detalles Bibliográficos
Autores principales: Bennett, Craig L., Dastidar, Somasish, Arnold, Frederick J., McKinstry, Spencer U., Stockford, Cameron, Freibaum, Brian D., Sopher, Bryce L., Wu, Meilin, Seidner, Glen, Joiner, William, Taylor, J. Paul, West, Ryan J. H., La Spada, Albert R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580588/
https://www.ncbi.nlm.nih.gov/pubmed/37845749
http://dx.doi.org/10.1186/s40478-023-01665-z

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