α-Synuclein propagation leads to synaptic abnormalities in the cortex through microglial synapse phagocytosis

The major neuropathologic feature of Parkinson’s disease is the presence of widespread intracellular inclusions of α-synuclein known as Lewy bodies. Evidence suggests that these misfolded protein inclusions spread through the brain with disease progression. Changes in synaptic function precede neuro...

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Detalles Bibliográficos
Autores principales: Pérez-Acuña, Dayana, Shin, Soo Jean, Rhee, Ka Hyun, Kim, Sang Jeong, Lee, Seung-Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580656/
https://www.ncbi.nlm.nih.gov/pubmed/37848910
http://dx.doi.org/10.1186/s13041-023-01059-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580656/
https://www.ncbi.nlm.nih.gov/pubmed/37848910
http://dx.doi.org/10.1186/s13041-023-01059-1

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