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α-Synuclein propagation leads to synaptic abnormalities in the cortex through microglial synapse phagocytosis
The major neuropathologic feature of Parkinson’s disease is the presence of widespread intracellular inclusions of α-synuclein known as Lewy bodies. Evidence suggests that these misfolded protein inclusions spread through the brain with disease progression. Changes in synaptic function precede neuro...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580656/ https://www.ncbi.nlm.nih.gov/pubmed/37848910 http://dx.doi.org/10.1186/s13041-023-01059-1 |