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Inflammatory Markers in Mother’s Own Milk and Infant Stool of Very Low Birthweight Infants
BACKGROUND: Mother’s breastmilk is the gold standard for feeding preterm infants. Preterm delivery may be precipitated by inflammatory maternal states, but little is known about milk cytokine profiles and how they correlate with markers of infant gut inflammation (i.e., stool calprotectin) in this v...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580668/ https://www.ncbi.nlm.nih.gov/pubmed/37653641 http://dx.doi.org/10.1177/08903344231192441 |
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author | Hoban, Rebecca Nir, Hadar Somerset, Emily Lewis, Jordan Unger, Sharon O’Connor, Deborah L. |
author_facet | Hoban, Rebecca Nir, Hadar Somerset, Emily Lewis, Jordan Unger, Sharon O’Connor, Deborah L. |
author_sort | Hoban, Rebecca |
collection | PubMed |
description | BACKGROUND: Mother’s breastmilk is the gold standard for feeding preterm infants. Preterm delivery may be precipitated by inflammatory maternal states, but little is known about milk cytokine profiles and how they correlate with markers of infant gut inflammation (i.e., stool calprotectin) in this vulnerable population. RESEARCH AIM: To assess cytokines and inflammatory markers in milk from parents of very preterm infants over time as well as correlations between milk and infant’s stool calprotectin. METHOD: This is a secondary analysis of milk samples collected during OptiMoM, a triple-blind randomized clinical trial of infants born < 1250 g (NCT02137473). Longitudinally collected samples were analyzed for cytokines, choline, and inflammatory markers (C-reactive protein [CRP], IFN-γ, IL-10, IL-1β, IL-1ra, IL-6, IL-8, TNF-α). Infant stools were collected for longitudinal calprotectin analysis. Generalized estimating equations quantified longitudinal profiles of milk markers and stool calprotectin, their associations, and the correlation between free choline and C-reactive protein over follow-up. RESULT: Participants included 92 parents and infants (median weeks of gestation 27.3, median birth weight 845 g, and prevalence of male infants 45%). In all, 212 milk samples and 94 corresponding stool calprotectin levels were collected 1–11 weeks postpartum. C-reactive protein was present in much higher concentrations than other markers, and was highest in Week 1 postpartum. It decreased over time. IL-8 and free choline also changed over time while other markers did not. There was no correlation between any milk markers and stool calprotectin. CONCLUSION: Milk from mothers of very preterm infants has detectable inflammatory markers, some of which change over time. Research is needed to determine if infant outcomes are associated with these markers. |
format | Online Article Text |
id | pubmed-10580668 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-105806682023-10-18 Inflammatory Markers in Mother’s Own Milk and Infant Stool of Very Low Birthweight Infants Hoban, Rebecca Nir, Hadar Somerset, Emily Lewis, Jordan Unger, Sharon O’Connor, Deborah L. J Hum Lact Clinical Perspectives BACKGROUND: Mother’s breastmilk is the gold standard for feeding preterm infants. Preterm delivery may be precipitated by inflammatory maternal states, but little is known about milk cytokine profiles and how they correlate with markers of infant gut inflammation (i.e., stool calprotectin) in this vulnerable population. RESEARCH AIM: To assess cytokines and inflammatory markers in milk from parents of very preterm infants over time as well as correlations between milk and infant’s stool calprotectin. METHOD: This is a secondary analysis of milk samples collected during OptiMoM, a triple-blind randomized clinical trial of infants born < 1250 g (NCT02137473). Longitudinally collected samples were analyzed for cytokines, choline, and inflammatory markers (C-reactive protein [CRP], IFN-γ, IL-10, IL-1β, IL-1ra, IL-6, IL-8, TNF-α). Infant stools were collected for longitudinal calprotectin analysis. Generalized estimating equations quantified longitudinal profiles of milk markers and stool calprotectin, their associations, and the correlation between free choline and C-reactive protein over follow-up. RESULT: Participants included 92 parents and infants (median weeks of gestation 27.3, median birth weight 845 g, and prevalence of male infants 45%). In all, 212 milk samples and 94 corresponding stool calprotectin levels were collected 1–11 weeks postpartum. C-reactive protein was present in much higher concentrations than other markers, and was highest in Week 1 postpartum. It decreased over time. IL-8 and free choline also changed over time while other markers did not. There was no correlation between any milk markers and stool calprotectin. CONCLUSION: Milk from mothers of very preterm infants has detectable inflammatory markers, some of which change over time. Research is needed to determine if infant outcomes are associated with these markers. SAGE Publications 2023-08-31 2023-11 /pmc/articles/PMC10580668/ /pubmed/37653641 http://dx.doi.org/10.1177/08903344231192441 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Clinical Perspectives Hoban, Rebecca Nir, Hadar Somerset, Emily Lewis, Jordan Unger, Sharon O’Connor, Deborah L. Inflammatory Markers in Mother’s Own Milk and Infant Stool of Very Low Birthweight Infants |
title | Inflammatory Markers in Mother’s Own Milk and Infant Stool of Very Low Birthweight Infants |
title_full | Inflammatory Markers in Mother’s Own Milk and Infant Stool of Very Low Birthweight Infants |
title_fullStr | Inflammatory Markers in Mother’s Own Milk and Infant Stool of Very Low Birthweight Infants |
title_full_unstemmed | Inflammatory Markers in Mother’s Own Milk and Infant Stool of Very Low Birthweight Infants |
title_short | Inflammatory Markers in Mother’s Own Milk and Infant Stool of Very Low Birthweight Infants |
title_sort | inflammatory markers in mother’s own milk and infant stool of very low birthweight infants |
topic | Clinical Perspectives |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580668/ https://www.ncbi.nlm.nih.gov/pubmed/37653641 http://dx.doi.org/10.1177/08903344231192441 |
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