Mortality of neuromyelitis optica spectrum disorder patients in an Argentinean population: A study from the RelevarEM registry

We aimed to evaluate mortality and causes of death among Argentinean neuromyelitis optica spectrum disorder (NMOSD) patients and identify predictors of death. Retrospective study included 158 NMOSD patients and 11 (7%) patients died after 11 years of follow-up for a total exposure time of 53,345 day...

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Detalles Bibliográficos
Autores principales: Carnero Contentti, Edgar, Lopez, Pablo A, Pettinicchi, Juan Pablo, Criniti, Juan, Pappolla, Agustín, Miguez, Jimena, Cristiano, Edgardo, Patrucco, Liliana, Liwacki, Susana, Tkachuk, Verónica, Balbuena, María E, Vrech, Carlos, Deri, Norma, Correale, Jorge, Marrodan, Mariano, Ysrraelit, María C, Leguizamon, Felisa, Luetic, Geraldine, Menichini, María L, Tavolini, Darío, Mainella, Carolina, Zanga, Gisela, Burgos, Marcos, Hryb, Javier, Barboza, Andrés, Lazaro, Luciana, Alonso, Ricardo, Fernández Liguori, Nora, Nadur, Débora, Alonso Serena, Marina, Caride, Alejandro, Paul, Friedemann, Rojas, Juan I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580714/
https://www.ncbi.nlm.nih.gov/pubmed/37854639
http://dx.doi.org/10.1177/20552173231205444
Descripción
Sumario:We aimed to evaluate mortality and causes of death among Argentinean neuromyelitis optica spectrum disorder (NMOSD) patients and identify predictors of death. Retrospective study included 158 NMOSD patients and 11 (7%) patients died after 11 years of follow-up for a total exposure time of 53,345 days with an overall incidence density of 2.06 × 10.000 patients/day (95% CI 1.75–2.68). Extensive cervical myelitis with respiratory failure (45%) was the most frequent cause of death. Older age (HR = 2.05, p = 0.002) and higher disability score (HR = 2.30, p < 0.001) at disease onset were independent predictors of death. We found an 11-year mortality rate of 7% in Argentinean NMOSD patients.

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