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Mortality of neuromyelitis optica spectrum disorder patients in an Argentinean population: A study from the RelevarEM registry
We aimed to evaluate mortality and causes of death among Argentinean neuromyelitis optica spectrum disorder (NMOSD) patients and identify predictors of death. Retrospective study included 158 NMOSD patients and 11 (7%) patients died after 11 years of follow-up for a total exposure time of 53,345 day...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
SAGE Publications
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580714/ https://www.ncbi.nlm.nih.gov/pubmed/37854639 http://dx.doi.org/10.1177/20552173231205444 |
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| author | Carnero Contentti, Edgar Lopez, Pablo A Pettinicchi, Juan Pablo Criniti, Juan Pappolla, Agustín Miguez, Jimena Cristiano, Edgardo Patrucco, Liliana Liwacki, Susana Tkachuk, Verónica Balbuena, María E Vrech, Carlos Deri, Norma Correale, Jorge Marrodan, Mariano Ysrraelit, María C Leguizamon, Felisa Luetic, Geraldine Menichini, María L Tavolini, Darío Mainella, Carolina Zanga, Gisela Burgos, Marcos Hryb, Javier Barboza, Andrés Lazaro, Luciana Alonso, Ricardo Fernández Liguori, Nora Nadur, Débora Alonso Serena, Marina Caride, Alejandro Paul, Friedemann Rojas, Juan I |
| author_facet | Carnero Contentti, Edgar Lopez, Pablo A Pettinicchi, Juan Pablo Criniti, Juan Pappolla, Agustín Miguez, Jimena Cristiano, Edgardo Patrucco, Liliana Liwacki, Susana Tkachuk, Verónica Balbuena, María E Vrech, Carlos Deri, Norma Correale, Jorge Marrodan, Mariano Ysrraelit, María C Leguizamon, Felisa Luetic, Geraldine Menichini, María L Tavolini, Darío Mainella, Carolina Zanga, Gisela Burgos, Marcos Hryb, Javier Barboza, Andrés Lazaro, Luciana Alonso, Ricardo Fernández Liguori, Nora Nadur, Débora Alonso Serena, Marina Caride, Alejandro Paul, Friedemann Rojas, Juan I |
| author_sort | Carnero Contentti, Edgar |
| collection | PubMed |
| description | We aimed to evaluate mortality and causes of death among Argentinean neuromyelitis optica spectrum disorder (NMOSD) patients and identify predictors of death. Retrospective study included 158 NMOSD patients and 11 (7%) patients died after 11 years of follow-up for a total exposure time of 53,345 days with an overall incidence density of 2.06 × 10.000 patients/day (95% CI 1.75–2.68). Extensive cervical myelitis with respiratory failure (45%) was the most frequent cause of death. Older age (HR = 2.05, p = 0.002) and higher disability score (HR = 2.30, p < 0.001) at disease onset were independent predictors of death. We found an 11-year mortality rate of 7% in Argentinean NMOSD patients. |
| format | Online Article Text |
| id | pubmed-10580714 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | SAGE Publications |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-105807142023-10-18 Mortality of neuromyelitis optica spectrum disorder patients in an Argentinean population: A study from the RelevarEM registry Carnero Contentti, Edgar Lopez, Pablo A Pettinicchi, Juan Pablo Criniti, Juan Pappolla, Agustín Miguez, Jimena Cristiano, Edgardo Patrucco, Liliana Liwacki, Susana Tkachuk, Verónica Balbuena, María E Vrech, Carlos Deri, Norma Correale, Jorge Marrodan, Mariano Ysrraelit, María C Leguizamon, Felisa Luetic, Geraldine Menichini, María L Tavolini, Darío Mainella, Carolina Zanga, Gisela Burgos, Marcos Hryb, Javier Barboza, Andrés Lazaro, Luciana Alonso, Ricardo Fernández Liguori, Nora Nadur, Débora Alonso Serena, Marina Caride, Alejandro Paul, Friedemann Rojas, Juan I Mult Scler J Exp Transl Clin Case Report We aimed to evaluate mortality and causes of death among Argentinean neuromyelitis optica spectrum disorder (NMOSD) patients and identify predictors of death. Retrospective study included 158 NMOSD patients and 11 (7%) patients died after 11 years of follow-up for a total exposure time of 53,345 days with an overall incidence density of 2.06 × 10.000 patients/day (95% CI 1.75–2.68). Extensive cervical myelitis with respiratory failure (45%) was the most frequent cause of death. Older age (HR = 2.05, p = 0.002) and higher disability score (HR = 2.30, p < 0.001) at disease onset were independent predictors of death. We found an 11-year mortality rate of 7% in Argentinean NMOSD patients. SAGE Publications 2023-10-17 /pmc/articles/PMC10580714/ /pubmed/37854639 http://dx.doi.org/10.1177/20552173231205444 Text en © The Author(s), 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
| spellingShingle | Case Report Carnero Contentti, Edgar Lopez, Pablo A Pettinicchi, Juan Pablo Criniti, Juan Pappolla, Agustín Miguez, Jimena Cristiano, Edgardo Patrucco, Liliana Liwacki, Susana Tkachuk, Verónica Balbuena, María E Vrech, Carlos Deri, Norma Correale, Jorge Marrodan, Mariano Ysrraelit, María C Leguizamon, Felisa Luetic, Geraldine Menichini, María L Tavolini, Darío Mainella, Carolina Zanga, Gisela Burgos, Marcos Hryb, Javier Barboza, Andrés Lazaro, Luciana Alonso, Ricardo Fernández Liguori, Nora Nadur, Débora Alonso Serena, Marina Caride, Alejandro Paul, Friedemann Rojas, Juan I Mortality of neuromyelitis optica spectrum disorder patients in an Argentinean population: A study from the RelevarEM registry |
| title | Mortality of neuromyelitis optica spectrum disorder patients in an Argentinean population: A study from the RelevarEM registry |
| title_full | Mortality of neuromyelitis optica spectrum disorder patients in an Argentinean population: A study from the RelevarEM registry |
| title_fullStr | Mortality of neuromyelitis optica spectrum disorder patients in an Argentinean population: A study from the RelevarEM registry |
| title_full_unstemmed | Mortality of neuromyelitis optica spectrum disorder patients in an Argentinean population: A study from the RelevarEM registry |
| title_short | Mortality of neuromyelitis optica spectrum disorder patients in an Argentinean population: A study from the RelevarEM registry |
| title_sort | mortality of neuromyelitis optica spectrum disorder patients in an argentinean population: a study from the relevarem registry |
| topic | Case Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580714/ https://www.ncbi.nlm.nih.gov/pubmed/37854639 http://dx.doi.org/10.1177/20552173231205444 |
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