Obesity in Late-Life as a Protective Factor Against Dementia and Dementia-Related Mortality

OBJECTIVE: We estimated the conversion from cognitively normal to mild cognitive impairment (MCI) to probable dementia and death for underweight, normal, overweight, and obese older adults, where the timing of examinations is associated with the severity of dementia. METHODS: We analyzed six waves o...

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Autores principales: Natale, Ginny, Zhang, Yun, Hanes, Douglas William, Clouston, Sean AP
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580725/
https://www.ncbi.nlm.nih.gov/pubmed/37391890
http://dx.doi.org/10.1177/15333175221111658
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author Natale, Ginny
Zhang, Yun
Hanes, Douglas William
Clouston, Sean AP
author_facet Natale, Ginny
Zhang, Yun
Hanes, Douglas William
Clouston, Sean AP
author_sort Natale, Ginny
collection PubMed
description OBJECTIVE: We estimated the conversion from cognitively normal to mild cognitive impairment (MCI) to probable dementia and death for underweight, normal, overweight, and obese older adults, where the timing of examinations is associated with the severity of dementia. METHODS: We analyzed six waves of the National Health and Aging Trends Study (NHATS). Body mass (BMI) was computed from height and weight. Multi-state survival models (MSMs) examined misclassification probability, time-to-event ratios, and cognitive decline. RESULTS: Participants (n = 6078) were 77 years old, 62% had overweight and/or obese BMI. After adjusting for the effects of cardiometabolic factors, age, sex, and race, obesity was protective against developing dementia (aHR=.44; 95%CI [.29-.67]) and dementia-related mortality (aHR=.63; 95%CI [.42-.95]). DISCUSSION: We found a negative relationship between obesity and dementia and dementia-related mortality, a finding that has been underreported in the literature. The continuing obesity epidemic might complicate the diagnosis and treatment of dementia.
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spelling pubmed-105807252023-11-15 Obesity in Late-Life as a Protective Factor Against Dementia and Dementia-Related Mortality Natale, Ginny Zhang, Yun Hanes, Douglas William Clouston, Sean AP Am J Alzheimers Dis Other Demen Article OBJECTIVE: We estimated the conversion from cognitively normal to mild cognitive impairment (MCI) to probable dementia and death for underweight, normal, overweight, and obese older adults, where the timing of examinations is associated with the severity of dementia. METHODS: We analyzed six waves of the National Health and Aging Trends Study (NHATS). Body mass (BMI) was computed from height and weight. Multi-state survival models (MSMs) examined misclassification probability, time-to-event ratios, and cognitive decline. RESULTS: Participants (n = 6078) were 77 years old, 62% had overweight and/or obese BMI. After adjusting for the effects of cardiometabolic factors, age, sex, and race, obesity was protective against developing dementia (aHR=.44; 95%CI [.29-.67]) and dementia-related mortality (aHR=.63; 95%CI [.42-.95]). DISCUSSION: We found a negative relationship between obesity and dementia and dementia-related mortality, a finding that has been underreported in the literature. The continuing obesity epidemic might complicate the diagnosis and treatment of dementia. 2023 /pmc/articles/PMC10580725/ /pubmed/37391890 http://dx.doi.org/10.1177/15333175221111658 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/Creative Commons Non Commercial No Derivs CC BY-NC-ND: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/) which permits non-commercial use, reproduction and distribution of the work as published without adaptation or alteration, without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Article
Natale, Ginny
Zhang, Yun
Hanes, Douglas William
Clouston, Sean AP
Obesity in Late-Life as a Protective Factor Against Dementia and Dementia-Related Mortality
title Obesity in Late-Life as a Protective Factor Against Dementia and Dementia-Related Mortality
title_full Obesity in Late-Life as a Protective Factor Against Dementia and Dementia-Related Mortality
title_fullStr Obesity in Late-Life as a Protective Factor Against Dementia and Dementia-Related Mortality
title_full_unstemmed Obesity in Late-Life as a Protective Factor Against Dementia and Dementia-Related Mortality
title_short Obesity in Late-Life as a Protective Factor Against Dementia and Dementia-Related Mortality
title_sort obesity in late-life as a protective factor against dementia and dementia-related mortality
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580725/
https://www.ncbi.nlm.nih.gov/pubmed/37391890
http://dx.doi.org/10.1177/15333175221111658
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