Cargando…

SARS-CoV-2 infection severity and mortality is modulated by repeat-mediated regulation of alternative splicing

Like single-stranded RNA viruses, SARS-CoV-2 hijacks the host transcriptional machinery for its own replication. Numerous traditional differential gene expression-based investigations have examined the diverse clinical symptoms caused by SARS-CoV-2 infection. The virus, on the other hand, also affec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mehta, Priyanka, Chattopadhyay, Partha, Ravi, Varsha, Tarai, Bansidhar, Budhiraja, Sandeep, Pandey, Rajesh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580830/ https://www.ncbi.nlm.nih.gov/pubmed/37604131 http://dx.doi.org/10.1128/spectrum.01351-23

Ejemplares similares

Transcriptomic study reveals lncRNA-mediated downregulation of innate immune and inflammatory response in the SARS-CoV-2 vaccination breakthrough infections
por: Chattopadhyay, Partha, et al.
Publicado: (2022)

Co-evolution of SARS-CoV-2 variants and host immune response trajectories underlie COVID-19 pandemic to epidemic transition
por: Maurya, Ranjeet, et al.
Publicado: (2023)

SARS-CoV-2 Mutations and COVID-19 Clinical Outcome: Mutation Global Frequency Dynamics and Structural Modulation Hold the Key
por: Maurya, Ranjeet, et al.
Publicado: (2022)

Longitudinal study across SARS-CoV-2 variants identifies transcriptionally active microbes (TAMs) associated with Delta severity
por: Devi, Priti, et al.
Publicado: (2023)

LncRNAs harbouring regulatory motifs within repeat elements modulate immune response towards COVID‐19 disease severity and clinical outcomes
por: Chattopadhyay, Partha, et al.
Publicado: (2022)

Intertwined Dysregulation of Ribosomal Proteins and Immune Response Delineates SARS-CoV-2 Vaccination Breakthroughs
por: Maurya, Ranjeet, et al.
Publicado: (2023)

Clinico-Genomic Analysis Reiterates Mild Symptoms Post-vaccination Breakthrough: Should We Focus on Low-Frequency Mutations?
por: Kanakan, Akshay, et al.
Publicado: (2022)

Mutational dynamics across VOCs in International travellers and Community transmission underscores importance of Spike-ACE2 interaction()
por: Mehta, Priyanka, et al.
Publicado: (2022)

Increased Abundance of Achromobacter xylosoxidans and Bacillus cereus in Upper Airway Transcriptionally Active Microbiome of COVID-19 Mortality Patients Indicates Role of Co-Infections in Disease Severity and Outcome
por: Devi, Priti, et al.
Publicado: (2022)

Early transcriptomic host response signatures in the serum of dengue patients provides insights into clinical pathogenesis and disease severity
por: Yadav, Aanchal, et al.
Publicado: (2023)

Transcriptionally active nasopharyngeal commensals and opportunistic microbial dynamics define mild symptoms in the COVID 19 vaccination breakthroughs
por: Devi, Priti, et al.
Publicado: (2023)

Respiratory Co-Infections: Modulators of SARS-CoV-2 Patients’ Clinical Sub-Phenotype
por: Mehta, Priyanka, et al.
Publicado: (2021)

Human‐host transcriptomic analysis reveals unique early innate immune responses in different sub‐phenotypes of COVID‐19
por: Maurya, Ranjeet, et al.
Publicado: (2022)

Syndromic approach to SARS-CoV-2 detection using QIAstat-Dx SARS-CoV-2 panel from clinical samples
por: Gupta, Akshita, et al.
Publicado: (2021)

P498 Pneumocystis Jirovecii pneumonia: Clinical profile and diagnostic modalities
por: Tarai, P Bansidhar
Publicado: (2022)

COVID-19 Risk Stratification and Mortality Prediction in Hospitalized Indian Patients: Harnessing clinical data for public health benefits
por: Alle, Shanmukh, et al.
Publicado: (2022)

Single-cell RNA-Seq reveals intracellular microbial diversity within immune cells during SARS-CoV-2 infection and recovery
por: Yadav, Sunita, et al.
Publicado: (2023)

Recurrent Challenges for Clinicians: Emergence of Methicillin-Resistant Staphylococcus aureus, Vancomycin Resistance, and Current Treatment Options
por: Tarai, Bansidhar, et al.
Publicado: (2013)

Co-infections as Modulators of Disease Outcome: Minor Players or Major Players?
por: Devi, Priti, et al.
Publicado: (2021)

CAG repeats mimic CUG repeats in the misregulation of alternative splicing
por: Mykowska, Agnieszka, et al.
Publicado: (2011)

Evaluation of mean monocyte volume in septicemia caused by Salmonella species
por: Kumar, Dilip, et al.
Publicado: (2018)

Multidrug-Resistant Candida auris Infections in Critically Ill Coronavirus Disease Patients, India, April–July 2020
por: Chowdhary, Anuradha, et al.
Publicado: (2020)

SARS-CoV-2 Lineage Tracking, and Evolving Trends Seen during Three Consecutive Peaks of Infection in Delhi, India: a Clinico-Genomic Study
por: Gautam, Pramod, et al.
Publicado: (2022)

SARS-CoV-2 VOCs, Mutational diversity and clinical outcome: Are they modulating drug efficacy by altered binding strength?
por: Saifi, Sheeba, et al.
Publicado: (2022)

DNA hypermethylation of alternatively spliced and repeat sequences in humans
por: Malousi, Andigoni, et al.
Publicado: (2012)

SARS-CoV-2 Variants of Concern and Variations within Their Genome Architecture: Does Nucleotide Distribution and Mutation Rate Alter the Functionality and Evolution of the Virus?
por: Ravi, Varsha, et al.
Publicado: (2022)

A High Frequency of Candida auris Blood Stream Infections in Coronavirus Disease 2019 Patients Admitted to Intensive Care Units, Northwestern India: A Case Control Study
por: Rajni, Ekadashi, et al.
Publicado: (2021)

Learning From Biological and Computational Machines: Importance of SARS-CoV-2 Genomic Surveillance, Mutations and Risk Stratification
por: Bhat, Shikha, et al.
Publicado: (2021)

Circulation of DENV-3 Genotype 3 during 2017 to 2018 in Delhi: A Single-Center Hospital-Based Study
por: Padhi, Abhishek, et al.
Publicado: (2021)

The SARS-CoV-2 UTR's Intrudes Host RBP's and Modulates Cellular Splicing
por: Singh, Anjali, et al.
Publicado: (2023)

Pharmacology of Modulators of Alternative Splicing
por: Bates, David O., et al.
Publicado: (2017)

Suppressed transcript diversity and immune response in COVID-19 ICU patients: a longitudinal study
por: Mehta, Priyanka, et al.
Publicado: (2023)

The Alternative Splicing Mutation Database: a hub for investigations of alternative splicing using mutational evidence
por: Bechtel, Jason M, et al.
Publicado: (2008)

Calculation of Splicing Potential from the Alternative Splicing Mutation Database
por: Bechtel, Jason M, et al.
Publicado: (2008)

Vaccine Breakthrough Infections by SARS-CoV-2 Variants after ChAdOx1 nCoV-19 Vaccination in Healthcare Workers
por: Kale, Pratibha, et al.
Publicado: (2021)

Alternative splicing modulation by G-quadruplexes
por: Georgakopoulos-Soares, Ilias, et al.
Publicado: (2022)

Dysregulated metal ion homeostasis underscores non-canonical function of CD8(+) T cell during COVID-19
por: Khare, Kriti, et al.
Publicado: (2023)

Alternative Splice in Alternative Lice
por: Tovar-Corona, Jaime M., et al.
Publicado: (2015)

Alternative splicing: a paradoxical qudo in eukaryotic genomes
por: Kashyap, Luv, et al.
Publicado: (2007)

Single-Cell Genomics: Enabling the Functional Elucidation of Infectious Diseases in Multi-Cell Genomes
por: Sahni, Shweta, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_gig9ut0b2lk7098arq54f3smg0