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Identification of Loliolide with Anti-Aging Properties from Scenedesmus deserticola JD052

Herein, different extracts of Scenedesmus deserticola JD052, a green microalga, were evaluated in vitro as a potential anti-aging bioagent. Although post-treatment of microalgal culture with either UV irradiation or high light illumination did not lead to a substantial difference in the effectivenes...

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Autores principales: Cho, Dae-Hyun, Yun, Jin-Ho, Heo, Jina, Lee, In-Kyoung, Lee, Yong-Jae, Bae, Seunghee, Yun, Bong-Sik, Kim, Hee-Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Microbiology and Biotechnology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580889/
https://www.ncbi.nlm.nih.gov/pubmed/37317620
http://dx.doi.org/10.4014/jmb.2304.04044
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author Cho, Dae-Hyun
Yun, Jin-Ho
Heo, Jina
Lee, In-Kyoung
Lee, Yong-Jae
Bae, Seunghee
Yun, Bong-Sik
Kim, Hee-Sik
author_facet Cho, Dae-Hyun
Yun, Jin-Ho
Heo, Jina
Lee, In-Kyoung
Lee, Yong-Jae
Bae, Seunghee
Yun, Bong-Sik
Kim, Hee-Sik
author_sort Cho, Dae-Hyun
collection PubMed
description Herein, different extracts of Scenedesmus deserticola JD052, a green microalga, were evaluated in vitro as a potential anti-aging bioagent. Although post-treatment of microalgal culture with either UV irradiation or high light illumination did not lead to a substantial difference in the effectiveness of microalgal extracts as a potential anti-UV agent, the results indicated the presence of a highly potent compound in ethyl acetate extract with more than 20% increase in the cellular viability of normal human dermal fibroblasts (nHDFs) compared with the negative control amended with DMSO. The subsequent fractionation of the ethyl acetate extract led to two bioactive fractions with high anti-UV property; one of the fractions was further separated down to a single compound. While electrospray ionization mass spectrometry (ESI-MS) and nuclear magnetic resonance (NMR) spectroscopy analysis identified this single compound as loliolide, its identification has been rarely reported in microalgae previously, prompting thorough systematic investigations into this novel compound for the nascent microalgal industry.
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spelling pubmed-105808892023-10-18 Identification of Loliolide with Anti-Aging Properties from Scenedesmus deserticola JD052 Cho, Dae-Hyun Yun, Jin-Ho Heo, Jina Lee, In-Kyoung Lee, Yong-Jae Bae, Seunghee Yun, Bong-Sik Kim, Hee-Sik J Microbiol Biotechnol Research article Herein, different extracts of Scenedesmus deserticola JD052, a green microalga, were evaluated in vitro as a potential anti-aging bioagent. Although post-treatment of microalgal culture with either UV irradiation or high light illumination did not lead to a substantial difference in the effectiveness of microalgal extracts as a potential anti-UV agent, the results indicated the presence of a highly potent compound in ethyl acetate extract with more than 20% increase in the cellular viability of normal human dermal fibroblasts (nHDFs) compared with the negative control amended with DMSO. The subsequent fractionation of the ethyl acetate extract led to two bioactive fractions with high anti-UV property; one of the fractions was further separated down to a single compound. While electrospray ionization mass spectrometry (ESI-MS) and nuclear magnetic resonance (NMR) spectroscopy analysis identified this single compound as loliolide, its identification has been rarely reported in microalgae previously, prompting thorough systematic investigations into this novel compound for the nascent microalgal industry. The Korean Society for Microbiology and Biotechnology 2023-09-28 2023-06-02 /pmc/articles/PMC10580889/ /pubmed/37317620 http://dx.doi.org/10.4014/jmb.2304.04044 Text en Copyright © 2023 by the authors. Licensee KMB https://creativecommons.org/licenses/by/4.0/This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Research article
Cho, Dae-Hyun
Yun, Jin-Ho
Heo, Jina
Lee, In-Kyoung
Lee, Yong-Jae
Bae, Seunghee
Yun, Bong-Sik
Kim, Hee-Sik
Identification of Loliolide with Anti-Aging Properties from Scenedesmus deserticola JD052
title Identification of Loliolide with Anti-Aging Properties from Scenedesmus deserticola JD052
title_full Identification of Loliolide with Anti-Aging Properties from Scenedesmus deserticola JD052
title_fullStr Identification of Loliolide with Anti-Aging Properties from Scenedesmus deserticola JD052
title_full_unstemmed Identification of Loliolide with Anti-Aging Properties from Scenedesmus deserticola JD052
title_short Identification of Loliolide with Anti-Aging Properties from Scenedesmus deserticola JD052
title_sort identification of loliolide with anti-aging properties from scenedesmus deserticola jd052
topic Research article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580889/
https://www.ncbi.nlm.nih.gov/pubmed/37317620
http://dx.doi.org/10.4014/jmb.2304.04044
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