The MprF homolog LysX synthesizes lysyl-diacylglycerol contributing to antibiotic resistance and virulence

Lysyl-diacylglycerol (Lys-DAG) was identified three decades ago in Mycobacterium phlei, but the biosynthetic pathway and function of this aminoacylated lipid have since remained uncharacterized. Combining genetic methods, mass spectrometry, and biochemical approaches, we show that the multiple pepti...

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Detalles Bibliográficos
Autores principales: Gill, Cameron P., Phan, Christopher, Platt, Vivien, Worrell, Danielle, Andl, Thomas, Roy, Hervé
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580965/
https://www.ncbi.nlm.nih.gov/pubmed/37768052
http://dx.doi.org/10.1128/spectrum.01429-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580965/
https://www.ncbi.nlm.nih.gov/pubmed/37768052
http://dx.doi.org/10.1128/spectrum.01429-23

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