Cargando…

The MprF homolog LysX synthesizes lysyl-diacylglycerol contributing to antibiotic resistance and virulence

Lysyl-diacylglycerol (Lys-DAG) was identified three decades ago in Mycobacterium phlei, but the biosynthetic pathway and function of this aminoacylated lipid have since remained uncharacterized. Combining genetic methods, mass spectrometry, and biochemical approaches, we show that the multiple pepti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gill, Cameron P., Phan, Christopher, Platt, Vivien, Worrell, Danielle, Andl, Thomas, Roy, Hervé
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580965/ https://www.ncbi.nlm.nih.gov/pubmed/37768052 http://dx.doi.org/10.1128/spectrum.01429-23

Ejemplares similares

LysX2 is a Mycobacterium tuberculosis membrane protein with an extracytoplasmic MprF-like domain
por: Boldrin, Francesca, et al.
Publicado: (2022)

Role of mprF1 and mprF2 in the Pathogenicity of Enterococcus faecalis
por: Bao, Yinyin, et al.
Publicado: (2012)

Insights into the Roles of Lipoteichoic Acids and MprF in Bacillus subtilis
por: Guyet, Aurélie, et al.
Publicado: (2023)

Phospholipid translocation captured in a bifunctional membrane protein MprF
por: Song, Danfeng, et al.
Publicado: (2021)

Alterations in Phospholipid Catabolism in Mycobacterium Tuberculosis LysX Mutant
por: Maloney, Erin, et al.
Publicado: (2011)

Too Much or Not Enough: The Role of mprF in Regulating Overall Phospholipid Content
por: Fozo, Elizabeth M.
Publicado: (2023)

Mutation on lysX from Mycobacterium avium hominissuis impacts the host–pathogen interaction and virulence phenotype
por: Kirubakar, Greana, et al.
Publicado: (2020)

Gain-of-Function Mutations in the Phospholipid Flippase MprF Confer Specific Daptomycin Resistance
por: Ernst, Christoph M., et al.
Publicado: (2018)

Sensitizing Staphylococcus aureus to antibacterial agents by decoding and blocking the lipid flippase MprF
por: Slavetinsky, Christoph J, et al.
Publicado: (2022)

Effect of a Point Mutation in mprF on Susceptibility to Daptomycin, Vancomycin, and Oxacillin in an MRSA Clinical Strain
por: Chen, Feng-Jui, et al.
Publicado: (2018)

Association of mprF mutations with cross-resistance to daptomycin and vancomycin in methicillin-resistant Staphylococcus aureus (MRSA)
por: Thitiananpakorn, Kanate, et al.
Publicado: (2020)

The Bacterial Defensin Resistance Protein MprF Consists of Separable Domains for Lipid Lysinylation and Antimicrobial Peptide Repulsion
por: Ernst, Christoph M., et al.
Publicado: (2009)

Evaluation of Daptomycin Non-Susceptible Staphylococcus aureus for Stability, Population Profiles, mprF Mutations, and Daptomycin Activity
por: Steed, Molly E., et al.
Publicado: (2013)

Phenotypic and Genotypic Characterization of Daptomycin-Resistant Methicillin-Resistant Staphylococcus aureus Strains: Relative Roles of mprF and dlt Operons
por: Mishra, Nagendra N., et al.
Publicado: (2014)

The Two-Domain LysX Protein of Mycobacterium tuberculosis Is Required for Production of Lysinylated Phosphatidylglycerol and Resistance to Cationic Antimicrobial Peptides
por: Maloney, Erin, et al.
Publicado: (2009)

Single nucleotide polymorphism leads to daptomycin resistance causing amino acid substitution—T345I in MprF of clinically isolated MRSA strains
por: Nakamura, Masaki, et al.
Publicado: (2021)

Daptomycin Resistant Staphylococcus aureus Clinical Strain With Novel Non-synonymous Mutations in the mprF and vraS Genes: A New Insight Into Daptomycin Resistance
por: Sabat, Artur J., et al.
Publicado: (2018)

Emergence of Daptomycin Resistance in Daptomycin-Naïve Rabbits with Methicillin-Resistant Staphylococcus aureus Prosthetic Joint Infection Is Associated with Resistance to Host Defense Cationic Peptides and mprF Polymorphisms
por: Mishra, Nagendra N., et al.
Publicado: (2013)

Rejection and killing, without MPR
por: Dove, Alan W.
Publicado: (2003)

Characterization of association of human mitochondrial lysyl-tRNA synthetase with HIV-1 Pol and tRNA(3)(Lys)
por: Khoder-Agha, Fawzi, et al.
Publicado: (2018)

Staphylococcus aureus Resistance to Human Defensins and Evasion of Neutrophil Killing via the Novel Virulence Factor Mprf Is Based on Modification of Membrane Lipids with l-Lysine
por: Peschel, Andreas, et al.
Publicado: (2001)

Diacylglycerol O-Acyltransferase Type-1 Synthesizes Retinyl Esters in the Retina and Retinal Pigment Epithelium
por: Kaylor, Joanna J., et al.
Publicado: (2015)

Decoding phage resistance by mpr and its role in survivability of Mycobacterium smegmatis
por: Seniya, Surya Pratap, et al.
Publicado: (2022)

The Interactome of Cancer-Related Lysyl Oxidase and Lysyl Oxidase-Like Proteins
por: Vallet, Sylvain D., et al.
Publicado: (2020)

Diacylglycerol kinase ζ controls diacylglycerol metabolism at the immunological synapse
por: Gharbi, Severine I., et al.
Publicado: (2011)

Multifunctional Lysyl Oxidases
por: Trackman, Philip C.
Publicado: (2023)

Expression and Purification of Human Membrane Progestin Receptor α (mPRα)
por: Hossain, Md. Babul, et al.
Publicado: (2015)

mPR-Specific Actions Influence Maintenance of the Blood–Brain Barrier (BBB)
por: Abou-Fadel, Johnathan, et al.
Publicado: (2022)

Ribavirin suppresses bacterial virulence by targeting LysR-type transcriptional regulators
por: Mandal, Rahul Shubhra, et al.
Publicado: (2016)

Verticillium dahliae LysM effectors differentially contribute to virulence on plant hosts
por: Kombrink, Anja, et al.
Publicado: (2017)

Engineering the Thermostability of the Mono- and Diacylglycerol Lipase SMG1 for the Synthesis of Diacylglycerols
por: Li, Lilang, et al.
Publicado: (2022)

Diacylglycerol Kinases: Shaping Diacylglycerol and Phosphatidic Acid Gradients to Control Cell Polarity
por: Baldanzi, Gianluca, et al.
Publicado: (2016)

Multiple Primary Recurrent Basaliomas (mPR-BCCs) of the Scalp with Cranial Bone Invasion
por: Tchernev, Georgi, et al.
Publicado: (2017)

Esitazione ed obbligo vaccinale in Emilia-Romagna: il caso della vaccinazione MPR
por: Gori, Davide, et al.
Publicado: (2019)

Origin and evolution of lysyl oxidases
por: Grau-Bové, Xavier, et al.
Publicado: (2015)

Lysyl Oxidase and the Tumor Microenvironment
por: Wang, Tong-Hong, et al.
Publicado: (2016)

Immunogenic recombinant Burkholderia pseudomallei MprA serine protease elicits protective immunity in mice
por: Chin, Chui-Yoke, et al.
Publicado: (2012)

Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR
por: Simonetti, Boris, et al.
Publicado: (2017)

Trichosanthin increases Granzyme B penetration into tumor cells by upregulation of CI-MPR on the cell surface
por: Li, Chunman, et al.
Publicado: (2017)

CT-guided biopsy of subdiaphragmatic small renal nodule with the coaxial technique using MPR images
por: Saba, Luca, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ff27n69lvdrdfhjjnom0402pfr