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La-related protein 4 is enriched in vaccinia virus factories and is required for efficient viral replication in primary human fibroblasts

In addition to the 3′-poly(A) tail, vaccinia virus mRNAs synthesized after viral DNA replication (post-replicative mRNAs) possess a 5′-poly(A) leader that confers a translational advantage in virally infected cells. These mRNAs are synthesized in viral factories, the cytoplasmic compartment where va...

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Detalles Bibliográficos
Autores principales: Dhungel, Pragyesh, Brahim Belhaouari, Djamal, Yang, Zhilong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581054/
https://www.ncbi.nlm.nih.gov/pubmed/37594266
http://dx.doi.org/10.1128/spectrum.01390-23