Murepavadin induces envelope stress response and enhances the killing efficacies of β-lactam antibiotics by impairing the outer membrane integrity of Pseudomonas aeruginosa

Pseudomonas aeruginosa is a ubiquitous opportunistic pathogen that can cause a variety of acute and chronic infections. The bacterium is highly resistant to numerous antibiotics. Murepavadin is a peptidomimetic antibiotic that blocks the function of P. aeruginosa lipopolysaccharide (LPS) transport p...

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Detalles Bibliográficos
Autores principales: Wei, Xiaoya, Gao, Jiacong, Xu, Congjuan, Pan, Xiaolei, Jin, Yongxin, Bai, Fang, Cheng, Zhihui, Lamont, Iain L., Pletzer, Daniel, Wu, Weihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581190/
https://www.ncbi.nlm.nih.gov/pubmed/37668398
http://dx.doi.org/10.1128/spectrum.01257-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581190/
https://www.ncbi.nlm.nih.gov/pubmed/37668398
http://dx.doi.org/10.1128/spectrum.01257-23

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