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Expression of transforming growth factor-β in oral submucous fibrosis: A systematic review

Oral submucous fibrosis (OSF) is a potentially malignant disorder characterised by inflammation and progressive fibrosis. Transforming growth factor-β (TGF-β) has been established as a master regulator of fibrosis in various organs; however, lack of systematic review on expression of TGF-β and its i...

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Autores principales: Bansal, Shivani P., Pereira, Treville, Desai, Rajiv S., Jena, Abinashi, Mehta, Vini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581301/
https://www.ncbi.nlm.nih.gov/pubmed/37854915
http://dx.doi.org/10.4103/jomfp.jomfp_536_22
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author Bansal, Shivani P.
Pereira, Treville
Desai, Rajiv S.
Jena, Abinashi
Mehta, Vini
author_facet Bansal, Shivani P.
Pereira, Treville
Desai, Rajiv S.
Jena, Abinashi
Mehta, Vini
author_sort Bansal, Shivani P.
collection PubMed
description Oral submucous fibrosis (OSF) is a potentially malignant disorder characterised by inflammation and progressive fibrosis. Transforming growth factor-β (TGF-β) has been established as a master regulator of fibrosis in various organs; however, lack of systematic review on expression of TGF-β and its isoforms in OSF restrict the understanding of their behaviour in its pathogenesis. Online electronic databases, such as PubMed Medline, Cochrane Library, Embase, and Scopus, were searched from their respective dates of inception till 31st March 2022. Human studies related to TGF-β expression in histopathologically diagnosed OSF cases, with or without malignant transformation, were included and assessed using a Cochrane risk of bias assessment tool: For non randomised studies of interventions (ACROBAT NRSI). The electronic literature search yielded 394 articles. Of those, ten articles met the inclusion criteria and involved total of 579 OSF patients. The risk of bias (RoB) was low to moderate. These studies demonstrated a significant positive expression of TGF-β and its isoforms in OSF compared to that in normal tissue samples. An increased pan TGF-β expression was observed in the early stages of OSF, and an increased expression of TGF-β1 and TGF-β2 were seen in advanced stages of OSF. Stage wise expression of TGF-β3 has not been discussed in the included studies. No significant relationship was observed between epithelial dysplasia and TGF-β expression in OSF. The distinct pattern in the expression of pan TGF-β, TGF-β1 and TGF-β2 in various stages of OSF indicates their different roles in OSF progression. We believe isoform targeted studies exploring stage wise expression of the marker will open new treatment avenues for OSF.
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spelling pubmed-105813012023-10-18 Expression of transforming growth factor-β in oral submucous fibrosis: A systematic review Bansal, Shivani P. Pereira, Treville Desai, Rajiv S. Jena, Abinashi Mehta, Vini J Oral Maxillofac Pathol Review Article Oral submucous fibrosis (OSF) is a potentially malignant disorder characterised by inflammation and progressive fibrosis. Transforming growth factor-β (TGF-β) has been established as a master regulator of fibrosis in various organs; however, lack of systematic review on expression of TGF-β and its isoforms in OSF restrict the understanding of their behaviour in its pathogenesis. Online electronic databases, such as PubMed Medline, Cochrane Library, Embase, and Scopus, were searched from their respective dates of inception till 31st March 2022. Human studies related to TGF-β expression in histopathologically diagnosed OSF cases, with or without malignant transformation, were included and assessed using a Cochrane risk of bias assessment tool: For non randomised studies of interventions (ACROBAT NRSI). The electronic literature search yielded 394 articles. Of those, ten articles met the inclusion criteria and involved total of 579 OSF patients. The risk of bias (RoB) was low to moderate. These studies demonstrated a significant positive expression of TGF-β and its isoforms in OSF compared to that in normal tissue samples. An increased pan TGF-β expression was observed in the early stages of OSF, and an increased expression of TGF-β1 and TGF-β2 were seen in advanced stages of OSF. Stage wise expression of TGF-β3 has not been discussed in the included studies. No significant relationship was observed between epithelial dysplasia and TGF-β expression in OSF. The distinct pattern in the expression of pan TGF-β, TGF-β1 and TGF-β2 in various stages of OSF indicates their different roles in OSF progression. We believe isoform targeted studies exploring stage wise expression of the marker will open new treatment avenues for OSF. Wolters Kluwer - Medknow 2023 2023-07-13 /pmc/articles/PMC10581301/ /pubmed/37854915 http://dx.doi.org/10.4103/jomfp.jomfp_536_22 Text en Copyright: © 2023 Journal of Oral and Maxillofacial Pathology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Bansal, Shivani P.
Pereira, Treville
Desai, Rajiv S.
Jena, Abinashi
Mehta, Vini
Expression of transforming growth factor-β in oral submucous fibrosis: A systematic review
title Expression of transforming growth factor-β in oral submucous fibrosis: A systematic review
title_full Expression of transforming growth factor-β in oral submucous fibrosis: A systematic review
title_fullStr Expression of transforming growth factor-β in oral submucous fibrosis: A systematic review
title_full_unstemmed Expression of transforming growth factor-β in oral submucous fibrosis: A systematic review
title_short Expression of transforming growth factor-β in oral submucous fibrosis: A systematic review
title_sort expression of transforming growth factor-β in oral submucous fibrosis: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581301/
https://www.ncbi.nlm.nih.gov/pubmed/37854915
http://dx.doi.org/10.4103/jomfp.jomfp_536_22
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