Glycosphingolipids are linked to elevated neurotransmission and neurodegeneration in a Drosophila model of Niemann Pick type C

The lipid storage disease Niemann Pick type C (NPC) causes neurodegeneration owing primarily to loss of NPC1. Here, we employed a Drosophila model to test links between glycosphingolipids, neurotransmission and neurodegeneration. We found that Npc1a nulls had elevated neurotransmission at the glutam...

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Detalles Bibliográficos
Autores principales: Eberwein, Anna E., Kulkarni, Swarat S., Rushton, Emma, Broadie, Kendal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581387/
https://www.ncbi.nlm.nih.gov/pubmed/37815467
http://dx.doi.org/10.1242/dmm.050206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581387/
https://www.ncbi.nlm.nih.gov/pubmed/37815467
http://dx.doi.org/10.1242/dmm.050206

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