Could (68)Ga-DOTA-UBI-29-41 Help Identify Chronic Osteomyelitis on PET/CT Images? A Pilot Study

This pilot study aimed to confirm the presence of infectious agents in infection foci using PET/CT imaging with (68)Ga-DOTA-UBI( (29–41)) in 7 patients with chronic osteomyelitis and with indications for surgical cleaning at the site of the infection focus. The whole-body PET/CT was performed on Bio...

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Detalles Bibliográficos
Autores principales: Nogueira, Solange Amorim, de Barboza, Marycel F., Dell’Aquila, Adriana M., Santos, Durval C. B, Osawa, Akemi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Interesting Images
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581417/
https://www.ncbi.nlm.nih.gov/pubmed/37756436
http://dx.doi.org/10.1097/RLU.0000000000004866
Descripción
Sumario:This pilot study aimed to confirm the presence of infectious agents in infection foci using PET/CT imaging with (68)Ga-DOTA-UBI( (29–41)) in 7 patients with chronic osteomyelitis and with indications for surgical cleaning at the site of the infection focus. The whole-body PET/CT was performed on Biograph mCT 40 PET/CT scanner (Siemens Healthineers); the image began 45–60 minutes postinjection of the radiotracer (148–260 MBq). This study demonstrated that, in 6 patients in whom the PET/CT was classified as positive for identified infectious foci, confirmed by culture of the secretion sample collected during surgery, only 1 patient in antibiotic therapy was negative.

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