Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

BACKGROUND AND AIMS: The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co−expressed with the MTTP gene that encodes for micr...

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Detalles Bibliográficos
Autores principales: van Zwol, Willemien, Rimbert, Antoine, Wolters, Justina C., Smit, Marieke, Bloks, Vincent W., Kloosterhuis, Niels J., Huijkman, Nicolette C. A., Koster, Mirjam H., Tharehalli, Umesh, de Neck, Simon M., Bournez, Colin, Fuh, Marceline M., Kuipers, Jeroen, Rajan, Sujith, de Bruin, Alain, Ginsberg, Henry N., van Westen, Gerard J. P., Hussain, M. Mahmood, Scheja, Ludger, Heeren, Joerg, Zimmerman, Philip, van de Sluis, Bart, Kuivenhoven, Jan Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Original Articles: Liver Pathobiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581432/
https://www.ncbi.nlm.nih.gov/pubmed/36053190
http://dx.doi.org/10.1002/hep.32709

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