Citalopram in vitro metabolism in a Beagle dog: A role for CYP2D15 in the production of toxic didesmethylcitalopram?

After administration of the serotonergic antidepressant citalopram (CIT) to Beagle dogs, the dogs may experience severe convulsive attacks in relation to the considerably higher plasma concentrations of the metabolite didesmethyl-CIT (DDCIT), when compared to those in humans medicated with CIT. This...

Descripción completa

Detalles Bibliográficos
Autores principales: Rochat, Bertrand, Paus, Erik, Maitre, Cedric, Baumann, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Czech Academy of Agricultural Sciences 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581520/
https://www.ncbi.nlm.nih.gov/pubmed/37982088
http://dx.doi.org/10.17221/65/2022-VETMED

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581520/
https://www.ncbi.nlm.nih.gov/pubmed/37982088
http://dx.doi.org/10.17221/65/2022-VETMED

Ejemplares similares