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Clinical infection of Brucella canis in a companion dog with discospondylitis in the Republic of Korea

A 2-year-old, spayed female, Bichon Frise dog was presented with reluctance to exercise, back pain, and frequent sitting down. Multiple osteolysis, periosteal proliferation, and sclerosis of the vertebral endplates of T11–13 were observed in the radiography, computed tomography, and magnetic resonan...

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Autores principales: Seo, Ju-Hee, Oh, Ye-In, Kim, Se-Hoon, Seo, Kyoung-Won, Kang, Byung-Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Czech Academy of Agricultural Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581522/
https://www.ncbi.nlm.nih.gov/pubmed/37982052
http://dx.doi.org/10.17221/37/2023-VETMED
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author Seo, Ju-Hee
Oh, Ye-In
Kim, Se-Hoon
Seo, Kyoung-Won
Kang, Byung-Jae
author_facet Seo, Ju-Hee
Oh, Ye-In
Kim, Se-Hoon
Seo, Kyoung-Won
Kang, Byung-Jae
author_sort Seo, Ju-Hee
collection PubMed
description A 2-year-old, spayed female, Bichon Frise dog was presented with reluctance to exercise, back pain, and frequent sitting down. Multiple osteolysis, periosteal proliferation, and sclerosis of the vertebral endplates of T11–13 were observed in the radiography, computed tomography, and magnetic resonance imaging. The bacterial culture of the urine specimen, the polymerase chain reaction (PCR) of the blood, and the antibody tests were positive for Brucella canis. Accordingly, discospondylitis caused by B. canis was diagnosed and doxycycline was administered. The clinical signs resolved and the culture and PCR results were negative afterwards. Doxycycline was discontinued after 6 months. The clinical signs recurred 2 weeks later, and the combination treatment of doxycycline and enrofloxacin was initiated. Though no clinical signs were observed after 9 months and the bacterial cultures and PCR were negative, the antibody titre remained at 1 : 200 or more. The dog will continue taking antibiotics until the antibody titre drops. To the best of our knowledge, this is the first case report of a clinical infection of B. canis associated with canine discospondylitis in the Republic of Korea. Although the clinical signs of brucellosis might improve with antibiotic treatment, the disease cannot be cured due to Brucella’s various strategies to evade host immune systems. Specifically, it can proliferate and replicate within the host cells, resulting in an environment that makes treatment less effective. Furthermore, owing to its zoonotic potential, owners and veterinarians should consider lifelong management or euthanasia.
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spelling pubmed-105815222023-11-17 Clinical infection of Brucella canis in a companion dog with discospondylitis in the Republic of Korea Seo, Ju-Hee Oh, Ye-In Kim, Se-Hoon Seo, Kyoung-Won Kang, Byung-Jae Vet Med (Praha) Case Report A 2-year-old, spayed female, Bichon Frise dog was presented with reluctance to exercise, back pain, and frequent sitting down. Multiple osteolysis, periosteal proliferation, and sclerosis of the vertebral endplates of T11–13 were observed in the radiography, computed tomography, and magnetic resonance imaging. The bacterial culture of the urine specimen, the polymerase chain reaction (PCR) of the blood, and the antibody tests were positive for Brucella canis. Accordingly, discospondylitis caused by B. canis was diagnosed and doxycycline was administered. The clinical signs resolved and the culture and PCR results were negative afterwards. Doxycycline was discontinued after 6 months. The clinical signs recurred 2 weeks later, and the combination treatment of doxycycline and enrofloxacin was initiated. Though no clinical signs were observed after 9 months and the bacterial cultures and PCR were negative, the antibody titre remained at 1 : 200 or more. The dog will continue taking antibiotics until the antibody titre drops. To the best of our knowledge, this is the first case report of a clinical infection of B. canis associated with canine discospondylitis in the Republic of Korea. Although the clinical signs of brucellosis might improve with antibiotic treatment, the disease cannot be cured due to Brucella’s various strategies to evade host immune systems. Specifically, it can proliferate and replicate within the host cells, resulting in an environment that makes treatment less effective. Furthermore, owing to its zoonotic potential, owners and veterinarians should consider lifelong management or euthanasia. Czech Academy of Agricultural Sciences 2023-07-28 /pmc/articles/PMC10581522/ /pubmed/37982052 http://dx.doi.org/10.17221/37/2023-VETMED Text en Copyright: © 2023 Seo et al. https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (https://creativecommons.org/licenses/by/4.0/) (CC BY-NC 4.0).
spellingShingle Case Report
Seo, Ju-Hee
Oh, Ye-In
Kim, Se-Hoon
Seo, Kyoung-Won
Kang, Byung-Jae
Clinical infection of Brucella canis in a companion dog with discospondylitis in the Republic of Korea
title Clinical infection of Brucella canis in a companion dog with discospondylitis in the Republic of Korea
title_full Clinical infection of Brucella canis in a companion dog with discospondylitis in the Republic of Korea
title_fullStr Clinical infection of Brucella canis in a companion dog with discospondylitis in the Republic of Korea
title_full_unstemmed Clinical infection of Brucella canis in a companion dog with discospondylitis in the Republic of Korea
title_short Clinical infection of Brucella canis in a companion dog with discospondylitis in the Republic of Korea
title_sort clinical infection of brucella canis in a companion dog with discospondylitis in the republic of korea
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581522/
https://www.ncbi.nlm.nih.gov/pubmed/37982052
http://dx.doi.org/10.17221/37/2023-VETMED
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