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Annexin A1 in the nervous and ocular systems
The therapeutic potential of Annexin A1, an important member of the Annexin superfamily, has become evident in results of experiments with multiple human systems and animal models. The anti-inflammatory and pro-resolving effects of Annexin A1 are characteristic of pathologies involving the nervous s...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581565/ https://www.ncbi.nlm.nih.gov/pubmed/37721289 http://dx.doi.org/10.4103/1673-5374.380882 |
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author | Wang, Aijia Zhang, Hong Li, Xing Zhao, Yin |
author_facet | Wang, Aijia Zhang, Hong Li, Xing Zhao, Yin |
author_sort | Wang, Aijia |
collection | PubMed |
description | The therapeutic potential of Annexin A1, an important member of the Annexin superfamily, has become evident in results of experiments with multiple human systems and animal models. The anti-inflammatory and pro-resolving effects of Annexin A1 are characteristic of pathologies involving the nervous system. In this review, we initially describe the expression sites of Annexin A1, then outline the mechanisms by which Annexin A1 maintains the neurological homeostasis through either formyl peptide receptor 2 or other molecular approaches; and, finally, we discuss the neuroregenerative potential qualities of Annexin A1. The eye and the nervous system are anatomically and functionally connected, but the association between visual system pathogenesis, especially in the retina, and Annexin A1 alterations has not been well summarized. Therefore, we explain the beneficial effects of Annexin A1 for ocular diseases, especially for retinal diseases and glaucoma on the basis of published findings, and we explore present and future delivery strategies for Annexin A1 to the retina. |
format | Online Article Text |
id | pubmed-10581565 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-105815652023-10-18 Annexin A1 in the nervous and ocular systems Wang, Aijia Zhang, Hong Li, Xing Zhao, Yin Neural Regen Res Review The therapeutic potential of Annexin A1, an important member of the Annexin superfamily, has become evident in results of experiments with multiple human systems and animal models. The anti-inflammatory and pro-resolving effects of Annexin A1 are characteristic of pathologies involving the nervous system. In this review, we initially describe the expression sites of Annexin A1, then outline the mechanisms by which Annexin A1 maintains the neurological homeostasis through either formyl peptide receptor 2 or other molecular approaches; and, finally, we discuss the neuroregenerative potential qualities of Annexin A1. The eye and the nervous system are anatomically and functionally connected, but the association between visual system pathogenesis, especially in the retina, and Annexin A1 alterations has not been well summarized. Therefore, we explain the beneficial effects of Annexin A1 for ocular diseases, especially for retinal diseases and glaucoma on the basis of published findings, and we explore present and future delivery strategies for Annexin A1 to the retina. Wolters Kluwer - Medknow 2023-07-20 /pmc/articles/PMC10581565/ /pubmed/37721289 http://dx.doi.org/10.4103/1673-5374.380882 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Wang, Aijia Zhang, Hong Li, Xing Zhao, Yin Annexin A1 in the nervous and ocular systems |
title | Annexin A1 in the nervous and ocular systems |
title_full | Annexin A1 in the nervous and ocular systems |
title_fullStr | Annexin A1 in the nervous and ocular systems |
title_full_unstemmed | Annexin A1 in the nervous and ocular systems |
title_short | Annexin A1 in the nervous and ocular systems |
title_sort | annexin a1 in the nervous and ocular systems |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581565/ https://www.ncbi.nlm.nih.gov/pubmed/37721289 http://dx.doi.org/10.4103/1673-5374.380882 |
work_keys_str_mv | AT wangaijia annexina1inthenervousandocularsystems AT zhanghong annexina1inthenervousandocularsystems AT lixing annexina1inthenervousandocularsystems AT zhaoyin annexina1inthenervousandocularsystems |