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Annexin A1 in the nervous and ocular systems

The therapeutic potential of Annexin A1, an important member of the Annexin superfamily, has become evident in results of experiments with multiple human systems and animal models. The anti-inflammatory and pro-resolving effects of Annexin A1 are characteristic of pathologies involving the nervous s...

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Detalles Bibliográficos
Autores principales: Wang, Aijia, Zhang, Hong, Li, Xing, Zhao, Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581565/
https://www.ncbi.nlm.nih.gov/pubmed/37721289
http://dx.doi.org/10.4103/1673-5374.380882
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author Wang, Aijia
Zhang, Hong
Li, Xing
Zhao, Yin
author_facet Wang, Aijia
Zhang, Hong
Li, Xing
Zhao, Yin
author_sort Wang, Aijia
collection PubMed
description The therapeutic potential of Annexin A1, an important member of the Annexin superfamily, has become evident in results of experiments with multiple human systems and animal models. The anti-inflammatory and pro-resolving effects of Annexin A1 are characteristic of pathologies involving the nervous system. In this review, we initially describe the expression sites of Annexin A1, then outline the mechanisms by which Annexin A1 maintains the neurological homeostasis through either formyl peptide receptor 2 or other molecular approaches; and, finally, we discuss the neuroregenerative potential qualities of Annexin A1. The eye and the nervous system are anatomically and functionally connected, but the association between visual system pathogenesis, especially in the retina, and Annexin A1 alterations has not been well summarized. Therefore, we explain the beneficial effects of Annexin A1 for ocular diseases, especially for retinal diseases and glaucoma on the basis of published findings, and we explore present and future delivery strategies for Annexin A1 to the retina.
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spelling pubmed-105815652023-10-18 Annexin A1 in the nervous and ocular systems Wang, Aijia Zhang, Hong Li, Xing Zhao, Yin Neural Regen Res Review The therapeutic potential of Annexin A1, an important member of the Annexin superfamily, has become evident in results of experiments with multiple human systems and animal models. The anti-inflammatory and pro-resolving effects of Annexin A1 are characteristic of pathologies involving the nervous system. In this review, we initially describe the expression sites of Annexin A1, then outline the mechanisms by which Annexin A1 maintains the neurological homeostasis through either formyl peptide receptor 2 or other molecular approaches; and, finally, we discuss the neuroregenerative potential qualities of Annexin A1. The eye and the nervous system are anatomically and functionally connected, but the association between visual system pathogenesis, especially in the retina, and Annexin A1 alterations has not been well summarized. Therefore, we explain the beneficial effects of Annexin A1 for ocular diseases, especially for retinal diseases and glaucoma on the basis of published findings, and we explore present and future delivery strategies for Annexin A1 to the retina. Wolters Kluwer - Medknow 2023-07-20 /pmc/articles/PMC10581565/ /pubmed/37721289 http://dx.doi.org/10.4103/1673-5374.380882 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review
Wang, Aijia
Zhang, Hong
Li, Xing
Zhao, Yin
Annexin A1 in the nervous and ocular systems
title Annexin A1 in the nervous and ocular systems
title_full Annexin A1 in the nervous and ocular systems
title_fullStr Annexin A1 in the nervous and ocular systems
title_full_unstemmed Annexin A1 in the nervous and ocular systems
title_short Annexin A1 in the nervous and ocular systems
title_sort annexin a1 in the nervous and ocular systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581565/
https://www.ncbi.nlm.nih.gov/pubmed/37721289
http://dx.doi.org/10.4103/1673-5374.380882
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