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Polyoxidovanadates a new therapeutic alternative for neurodegenerative and aging diseases
Aging is a natural phenomenon characterized by a progressive decline in physiological integrity, leading to a deterioration of cognitive function and increasing the risk of suffering from chronic-degenerative diseases, including cardiovascular diseases, osteoporosis, cancer, diabetes, and neurodegen...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581577/ https://www.ncbi.nlm.nih.gov/pubmed/37721286 http://dx.doi.org/10.4103/1673-5374.380877 |
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author | Gonzalez-Cano, Sonia Irais Flores, Gonzalo Guevara, Jorge Morales-Medina, Julio Cesar Treviño, Samuel Diaz, Alfonso |
author_facet | Gonzalez-Cano, Sonia Irais Flores, Gonzalo Guevara, Jorge Morales-Medina, Julio Cesar Treviño, Samuel Diaz, Alfonso |
author_sort | Gonzalez-Cano, Sonia Irais |
collection | PubMed |
description | Aging is a natural phenomenon characterized by a progressive decline in physiological integrity, leading to a deterioration of cognitive function and increasing the risk of suffering from chronic-degenerative diseases, including cardiovascular diseases, osteoporosis, cancer, diabetes, and neurodegeneration. Aging is considered the major risk factor for Parkinson’s and Alzheimer’s disease develops. Likewise, diabetes and insulin resistance constitute additional risk factors for developing neurodegenerative disorders. Currently, no treatment can effectively reverse these neurodegenerative pathologies. However, some antidiabetic drugs have opened the possibility of being used against neurodegenerative processes. In the previous framework, Vanadium species have demonstrated a notable antidiabetic effect. Our research group evaluated polyoxidovanadates such as decavanadate and metforminium-decavanadate with preventive and corrective activity on neurodegeneration in brain-specific areas from rats with metabolic syndrome. The results suggest that these polyoxidovanadates induce neuronal and cognitive restoration mechanisms. This review aims to describe the therapeutic potential of polyoxidovanadates as insulin-enhancer agents in the brain, constituting a therapeutic alternative for aging and neurodegenerative diseases. |
format | Online Article Text |
id | pubmed-10581577 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-105815772023-10-18 Polyoxidovanadates a new therapeutic alternative for neurodegenerative and aging diseases Gonzalez-Cano, Sonia Irais Flores, Gonzalo Guevara, Jorge Morales-Medina, Julio Cesar Treviño, Samuel Diaz, Alfonso Neural Regen Res Review Aging is a natural phenomenon characterized by a progressive decline in physiological integrity, leading to a deterioration of cognitive function and increasing the risk of suffering from chronic-degenerative diseases, including cardiovascular diseases, osteoporosis, cancer, diabetes, and neurodegeneration. Aging is considered the major risk factor for Parkinson’s and Alzheimer’s disease develops. Likewise, diabetes and insulin resistance constitute additional risk factors for developing neurodegenerative disorders. Currently, no treatment can effectively reverse these neurodegenerative pathologies. However, some antidiabetic drugs have opened the possibility of being used against neurodegenerative processes. In the previous framework, Vanadium species have demonstrated a notable antidiabetic effect. Our research group evaluated polyoxidovanadates such as decavanadate and metforminium-decavanadate with preventive and corrective activity on neurodegeneration in brain-specific areas from rats with metabolic syndrome. The results suggest that these polyoxidovanadates induce neuronal and cognitive restoration mechanisms. This review aims to describe the therapeutic potential of polyoxidovanadates as insulin-enhancer agents in the brain, constituting a therapeutic alternative for aging and neurodegenerative diseases. Wolters Kluwer - Medknow 2023-07-20 /pmc/articles/PMC10581577/ /pubmed/37721286 http://dx.doi.org/10.4103/1673-5374.380877 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Gonzalez-Cano, Sonia Irais Flores, Gonzalo Guevara, Jorge Morales-Medina, Julio Cesar Treviño, Samuel Diaz, Alfonso Polyoxidovanadates a new therapeutic alternative for neurodegenerative and aging diseases |
title | Polyoxidovanadates a new therapeutic alternative for neurodegenerative and aging diseases |
title_full | Polyoxidovanadates a new therapeutic alternative for neurodegenerative and aging diseases |
title_fullStr | Polyoxidovanadates a new therapeutic alternative for neurodegenerative and aging diseases |
title_full_unstemmed | Polyoxidovanadates a new therapeutic alternative for neurodegenerative and aging diseases |
title_short | Polyoxidovanadates a new therapeutic alternative for neurodegenerative and aging diseases |
title_sort | polyoxidovanadates a new therapeutic alternative for neurodegenerative and aging diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581577/ https://www.ncbi.nlm.nih.gov/pubmed/37721286 http://dx.doi.org/10.4103/1673-5374.380877 |
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