Cargando…

Activity of Type II RAF Inhibitor Tovorafenib in a Pediatric Patient With a Recurrent Spindle Cell Sarcoma Harboring a Novel SNX8-BRAF Gene Fusion

Detalles Bibliográficos
Autores principales:	Offer, Katharine, McGuire, Michael T., Song, Kunchang, Goldfischer, Michael J., Davare, Monika A., Corless, Christopher L., Beadling, Carol, Neff, Tanaya, Cox, Michael C., Govinda Raju, Sandya, Blackman, Samuel C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer Health 2023
Materias:	Case Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581647/ https://www.ncbi.nlm.nih.gov/pubmed/37410972 http://dx.doi.org/10.1200/PO.23.00065

Ejemplares similares

Structure and RAF family kinase isoform selectivity of type II RAF inhibitors tovorafenib and naporafenib
por: Tkacik, Emre, et al.
Publicado: (2023)

Phase 1 study of the pan-RAF inhibitor tovorafenib in patients with advanced solid tumors followed by dose expansion in patients with metastatic melanoma
por: Rasco, Drew W., et al.
Publicado: (2023)

LGG-09. CLINICAL ACTIVITY OF PAN-RAF INHIBITOR TOVORAFENIB IN THE REGISTRATIONAL PEDIATRIC LOW-GRADE GLIOMA ARM OF THE PHASE 2 FIREFLY-1 (PNOC026) STUDY
por: Kilburn, Lindsay, et al.
Publicado: (2023)

Molecular profiling of pre- and post-treatment pediatric high-grade astrocytomas reveals acquired increased tumor mutation burden in a subset of recurrences
por: Wood, Matthew D., et al.
Publicado: (2023)

Targeted therapy by combined inhibition of the RAF and mTOR kinases in malignant spindle cell neoplasm harboring the KIAA1549-BRAF fusion protein
por: Subbiah, Vivek, et al.
Publicado: (2014)

Mechanisms of targeted therapy resistance in a pediatric glioma driven by ETV6-NTRK3 fusion
por: Keddy, Clare, et al.
Publicado: (2021)

Adding SNX to the mix: SNX9 drives filopodia biogenesis
por: Lebek, Nadine M., et al.
Publicado: (2020)

Sustained Response to the Mitogen-Activated Extracellular Kinase Inhibitor Trametinib in a Spindle Cell Sarcoma Harboring a QKI-RAF1 Gene Fusion
por: Panet, François, et al.
Publicado: (2022)

A heterodimeric SNX4–SNX7 SNX-BAR autophagy complex coordinates ATG9A trafficking for efficient autophagosome assembly
por: Antón, Zuriñe, et al.
Publicado: (2020)

Canonical and Non-Canonical Roles of SNX1 and SNX2 in Endosomal Membrane Dynamics
por: Da Graça, Juliane, et al.
Publicado: (2023)

SNX1 hugs the curves
por: LeBrasseur, Nicole
Publicado: (2004)

The SNX-PX-BAR Family in Macropinocytosis: The Regulation of Macropinosome Formation by SNX-PX-BAR Proteins
por: Wang, Jack T. H., et al.
Publicado: (2010)

Activity of the Highly Specific RET Inhibitor Selpercatinib (LOXO-292) in Pediatric Patients With Tumors Harboring RET Gene Alterations
por: Ortiz, Michael V., et al.
Publicado: (2020)

Lipid trafficking by yeast Snx4 family SNX-BAR proteins promotes autophagy and vacuole membrane fusion
por: Ma, Mengxiao, et al.
Publicado: (2018)

A SNX1–SNX2–VAPB partnership regulates endosomal membrane rewiring in response to nutritional stress
por: Da Graça, Juliane, et al.
Publicado: (2022)

Functional impact and targetability of PI3KCA, GNAS, and PTEN mutations in a spindle cell rhabdomyosarcoma with MYOD1 L122R mutation
por: Choo, Florence, et al.
Publicado: (2022)

RAF inhibitors transactivate RAF dimers and ERK signaling in cells with wild-type BRAF
por: Poulikakos, Poulikos I., et al.
Publicado: (2010)

A role for SNX5 in the regulation of macropinocytosis
por: Lim, Jet Phey, et al.
Publicado: (2008)

SNX12 Role in Endosome Membrane Transport
por: Pons, Véronique, et al.
Publicado: (2012)

Regulation of the endosomal SNX27-retromer by OTULIN
por: Stangl, Aurelia, et al.
Publicado: (2019)

SNX19 restricts endolysosome motility through contacts with the endoplasmic reticulum
por: Saric, Amra, et al.
Publicado: (2021)

The VINE complex is an endosomal VPS9-domain GEF and SNX-BAR coat
por: Shortill, Shawn P, et al.
Publicado: (2022)

MAP kinase meets mitosis: A role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation
por: Rosner, Marsha Rich
Publicado: (2007)

The Sorting Nexin Genes ChSNX4 and ChSNX41 Are Required for Reproductive Development, Stress Adaption and Virulence in Cochliobolus heterostrophus
por: Yu, Huilin, et al.
Publicado: (2022)

BRAF Mutant Gastrointestinal Stromal Tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance
por: Falchook, G.S., et al.
Publicado: (2013)

Recruitment of the SNX17-Retriever recycling pathway regulates synaptic function and plasticity
por: Rivero-Ríos, Pilar, et al.
Publicado: (2023)

The Role of Snx41-Based Pexophagy in Magnaporthe Development
por: Deng, Yizhen, et al.
Publicado: (2013)

A direct role for SNX9 in the biogenesis of filopodia
por: Jarsch, Iris K., et al.
Publicado: (2020)

Filling in the gaps: SNX-RGS proteins as multiorganelle tethers
por: Hariri, Hanaa, et al.
Publicado: (2022)

RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition
por: Jin, Ting, et al.
Publicado: (2017)

Antibody–drug conjugates harboring a kinesin spindle protein inhibitor with immunostimulatory properties
por: Sommer, Anette, et al.
Publicado: (2022)

SNX20AR/MiRNA-301a-3p/SNX20 Axis Associated With Cell Proliferation and Immune Infiltration in Lung Adenocarcinoma
por: Yuan, Yixiao, et al.
Publicado: (2021)

Two cases of spindle cell tumors with S100 and CD34 co-expression showing novel RAF1 fusions
por: Gong, Li-Hua, et al.
Publicado: (2022)

SNX4 in Complex with Clathrin and Dynein: Implications for Endosome Movement
por: Skånland, Sigrid S., et al.
Publicado: (2009)

SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts
por: Stattin, Eva-Lena, et al.
Publicado: (2017)

Mechanism of cargo recognition by retromer-linked SNX-BAR proteins
por: Yong, Xin, et al.
Publicado: (2020)

The cryo-EM structure of the SNX–BAR Mvp1 tetramer
por: Sun, Dapeng, et al.
Publicado: (2020)

Lymphatic fate determination: Playing RAF with ERK
por: Deng, Yong, et al.
Publicado: (2013)

Snx14 Regulates Neuronal Excitability, Promotes Synaptic Transmission, and Is Imprinted in the Brain of Mice
por: Huang, Hsien-Sung, et al.
Publicado: (2014)

SNX9 determines the surface levels of integrin β1 in vascular endothelial cells: Implication in poor prognosis of human colorectal cancers overexpressing SNX9
por: Tanigawa, Kazufumi, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_e5iuikcg2liaobcbohe98n4lb2