A multi-omics integrative approach unravels novel genes and pathways associated with senescence escape after targeted therapy in NRAS mutant melanoma

Therapy Induced Senescence (TIS) leads to sustained growth arrest of cancer cells. The associated cytostasis has been shown to be reversible and cells escaping senescence further enhance the aggressiveness of cancers. Chemicals specifically targeting senescent cells, so-called senolytics, constitute...

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Detalles Bibliográficos
Autores principales: Gureghian, Vincent, Herbst, Hailee, Kozar, Ines, Mihajlovic, Katarina, Malod-Dognin, Noël, Ceddia, Gaia, Angeli, Cristian, Margue, Christiane, Randic, Tijana, Philippidou, Demetra, Nomigni, Milène Tetsi, Hemedan, Ahmed, Tranchevent, Leon-Charles, Longworth, Joseph, Bauer, Mark, Badkas, Apurva, Gaigneaux, Anthoula, Muller, Arnaud, Ostaszewski, Marek, Tolle, Fabrice, Pržulj, Nataša, Kreis, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581906/
https://www.ncbi.nlm.nih.gov/pubmed/37420093
http://dx.doi.org/10.1038/s41417-023-00640-z

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