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Genome-wide association study for growth traits in Blanco Orejinegro and Romosinuano cattle

Growth traits are economically important characteristics for the genetic improvement of local cattle breeds. Genome-wide association studies (GWAS) provide valuable information to enhance the understanding on the genetics of complex traits. The aim of this study was to perform a GWAS to identify gen...

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Autores principales: Bejarano, Diego H., Martínez, Rodrigo A., Rocha, Juan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581918/
https://www.ncbi.nlm.nih.gov/pubmed/37848724
http://dx.doi.org/10.1007/s11250-023-03743-9
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author Bejarano, Diego H.
Martínez, Rodrigo A.
Rocha, Juan F.
author_facet Bejarano, Diego H.
Martínez, Rodrigo A.
Rocha, Juan F.
author_sort Bejarano, Diego H.
collection PubMed
description Growth traits are economically important characteristics for the genetic improvement of local cattle breeds. Genome-wide association studies (GWAS) provide valuable information to enhance the understanding on the genetics of complex traits. The aim of this study was to perform a GWAS to identify genomic regions and genes associated to birth weight, weaning weight adjusted for 240 days, 16 months, and 24 months weight in Romosinuano (ROMO) and Blanco Orejinegro (BON) cattle. A single-step genomic-BLUP was implemented using 596 BON and 569 ROMO individuals that were genotyped with an Illumina BovineSNP50 BeadChip. There were 25 regions of interest identified on different chromosomes, with few of them simultaneously associated with two or more growth traits and some were common to both breeds. The gene mapping allowed to find 173 annotations on these regions, from which 49 represent potential candidate genes with known growth-related functions in cattle and other species. Among the regions that were associated with several growth traits, that at 24 – 27 MB of BTA14, has important candidate genes such as LYPLA1, XKR4, TMEM68 and PLAG1. Another region of interest at 0.40–0.77 Mb of BTA23 was identified in both breeds, containing KHDRBS2 as a potential candidate gene influencing body weight. Future studies targeting these regions could provide more knowledge to uncover the genetic architecture underlying growth traits in BON and ROMO cattle. The genomic regions and genes identified in this study could be used to improve the prediction of genetic merit for growth traits in these creole cattle breeds.
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spelling pubmed-105819182023-10-19 Genome-wide association study for growth traits in Blanco Orejinegro and Romosinuano cattle Bejarano, Diego H. Martínez, Rodrigo A. Rocha, Juan F. Trop Anim Health Prod Regular Articles Growth traits are economically important characteristics for the genetic improvement of local cattle breeds. Genome-wide association studies (GWAS) provide valuable information to enhance the understanding on the genetics of complex traits. The aim of this study was to perform a GWAS to identify genomic regions and genes associated to birth weight, weaning weight adjusted for 240 days, 16 months, and 24 months weight in Romosinuano (ROMO) and Blanco Orejinegro (BON) cattle. A single-step genomic-BLUP was implemented using 596 BON and 569 ROMO individuals that were genotyped with an Illumina BovineSNP50 BeadChip. There were 25 regions of interest identified on different chromosomes, with few of them simultaneously associated with two or more growth traits and some were common to both breeds. The gene mapping allowed to find 173 annotations on these regions, from which 49 represent potential candidate genes with known growth-related functions in cattle and other species. Among the regions that were associated with several growth traits, that at 24 – 27 MB of BTA14, has important candidate genes such as LYPLA1, XKR4, TMEM68 and PLAG1. Another region of interest at 0.40–0.77 Mb of BTA23 was identified in both breeds, containing KHDRBS2 as a potential candidate gene influencing body weight. Future studies targeting these regions could provide more knowledge to uncover the genetic architecture underlying growth traits in BON and ROMO cattle. The genomic regions and genes identified in this study could be used to improve the prediction of genetic merit for growth traits in these creole cattle breeds. Springer Netherlands 2023-10-17 2023 /pmc/articles/PMC10581918/ /pubmed/37848724 http://dx.doi.org/10.1007/s11250-023-03743-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Regular Articles
Bejarano, Diego H.
Martínez, Rodrigo A.
Rocha, Juan F.
Genome-wide association study for growth traits in Blanco Orejinegro and Romosinuano cattle
title Genome-wide association study for growth traits in Blanco Orejinegro and Romosinuano cattle
title_full Genome-wide association study for growth traits in Blanco Orejinegro and Romosinuano cattle
title_fullStr Genome-wide association study for growth traits in Blanco Orejinegro and Romosinuano cattle
title_full_unstemmed Genome-wide association study for growth traits in Blanco Orejinegro and Romosinuano cattle
title_short Genome-wide association study for growth traits in Blanco Orejinegro and Romosinuano cattle
title_sort genome-wide association study for growth traits in blanco orejinegro and romosinuano cattle
topic Regular Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581918/
https://www.ncbi.nlm.nih.gov/pubmed/37848724
http://dx.doi.org/10.1007/s11250-023-03743-9
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